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Neue Entwicklungen in der Dermatologie pp 41–47Cite as

Neue Erkenntnisse über die Pathogenese des allergischen Kontaktekzems

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Zusammenfassung

Aufgrund von Literaturangaben und eigener experimenteller Arbeit wird der Entstehungsmechanismus des experimentellen Kontaktekzems wie folgt dargestellt:

Spezifische antigen-reaktive T-Lymphocyten werden durch einen antigenen Komplex, welcher durch Applikation des Haptens auf die Haut gebildet wird, stimuliert. Dabei spielen die Langerhans-Zellen in der Haut eine ausschlaggebende Rolle.

Aktivierte Lymphocyten proliferieren in der Thymus-abhängigen Zone des regionalen Lymph knotens, wodurch Effektor- und Memoryzellen entstehen. Nach einem wiederholten Kontakt mit dem Hapten setzen die Effektorzellen Mediatoren frei, die eine Entzündungsreaktion induzieren. Aus den Memoryzellen bilden sich weitere Effektorzellen, die den Kontaktüberempfindlichkeits- grad verstärken (booster effect).

Summary

On the basis of literature and experimental work the mechanism of the development of experimental allergic dermatitis is reviewed.

Specific antigen-reactive T-lymphocytes are stimulated by the antigenic complex formed upon the application of the hapten to the skin. Langerhans cells in the skin play in this process a decisive role. Activated lymphocytes proliferate in thymus dependent area of the draining lymphnode and differentiate into effector and memory cells. The former react to a repeated application of the hapten with release of mediators inducing an inflammatory skin reaction. The latter produce further effector cells thus enhancing the degree of contact sensitivity (booster effect).

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Author information

Authors and Affiliations

  1. Abt. für Pharmazeutische Forschung, F. Hoffmann-La Roche & Co. AG, Basel, Schweiz, Germany

    L. Polak

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  1. L. Polak
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Editors and Affiliations

  1. Erlangen, Germany

    O. P. Hornstein

  2. Münster-Hornheide, Germany

    M. Hundeiker

  3. Mannheim, Germany

    J. Schönfeld

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© 1987 Springer-Verlag Berlin Heidelberg

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Polak, L. (1987). Neue Erkenntnisse über die Pathogenese des allergischen Kontaktekzems. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72828-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-72828-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18063-0

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