Abstract
Asthmatic characteristics demonstrate a circadian variation in airway calibre; airflow is generally maximum in the afternoon and early evening, and reduced at night and early morning [1]. The majority of asthmatics demonstrate this phenomenon with increased early morning symptoms at some time during their disease process [2]. In fact, a number of patients who are asymptomatic during the day may only experience symptoms at night and in the early morning [3]. This variation in airway calibre has been correlated with asthmatic deaths, most of which occur at night [4], and finally to adequately control asthmatic symptoms, one must control this early morning dipping pattern.
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References
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© 1987 Springer-Verlag, Berlin Heidelberg New York
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Arkinstall, W.W., Atkins, M.E., Harrison, D., Stewart, J.H. (1987). Clinical Evaluation of a New Theophylline Strategy: Evening Dosing with Once a Day Uniphyl. In: Dethlefsen, U., Matthys, H. (eds) Fokus — Atemwegserkrankungen heute. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72768-9_21
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DOI: https://doi.org/10.1007/978-3-642-72768-9_21
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