Clinical Chronopharmacology and Chronotherapy of Asthma
As a result of endogenous biological rhythms both desired and undesired effects of a therapeutic agent vary as a function of the time at which it is given in the 24 h scale among other periods. Emphasis will be given here to circadian (≃24 h) chronopharmacology and chronotherapy. A better understanding of these pre-dictable changes can be reached by using several new concepts (Reinberg 1976). Chronopharmacokinetics (or chronokinetics, Reinberg 1976, Sturtevant 1976) means circadian changes of parameters and curve patterns used to characterize the pharmacokinetics of an agent. Chronesthesy (Reinberg 1976) indicates circadian changes in the susceptibility of target biosystems to an agent and involves receptors, cells, tissues, organs and organ systems. The chronergy (Reinberg 1976) of an agent designates its overall effects on the organism as a result of both its chronokinetics and the chronesthesy of target biosystems. Circadian changes in desired effects are usually namend chronoeffectiveness while time dependent changes in undesired effects are described as chronotolerance.
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- Bruguerolle B (1984) Chronopharmacologie. Ellipses, Edition Marketing, ParisGoogle Scholar
- Gaultier C, Reinberg A, Girard F (1977) Circadian rhythms in lung resistance and dynamic lung compliance of healthy children. Effects of two bronchodilators. Respir Physiol 31: 169–182Google Scholar
- Krieger DT (1979) Endocrine Rhythms. Raven Press, New YorkGoogle Scholar
- Lemmer B (1984) Chronopharmakologie, 2nd edn. Wissenschaftliche Verlagsgesellschaft StuttgartGoogle Scholar
- Postma D, Koether G, Meurs H, Keyser J (1984) Slow release terbutaline in nocturnal bronchial obstruction: relation of terbutaline dosage and blood levels with circadian changes in peak flow values. Ann Rev Chronopharmacol 1:101–108Google Scholar
- Reinberg A, Clench J, Ghata J, Halberg F, Abulker C, Dupont J, Zagulla-Mally Z (1975) Rythmes circadiens des parametres de l’excretion urinaire du salicylate (chronopharmacocinetique) chez l’homme adulte sain. C R Acad Sci Paris 280: 1697–1699Google Scholar
- Reinberg A, Ghata J, Halberg F, Apfelbaum M, Gervais P, Boudon P, Abulker Ch, Dupont J (1971) Distribution temporelle du traitement de l’insuffisance corticosurrenalienne. Essai de chronotherapeutique. Ann Endocrinol (Paris) 32: 566–573Google Scholar
- Reinberg A, Guillet P, Gervais P, Ghata J, Vignaud D, Abulker C (1977) One-month chronotherapy (Dutimelan 8–15 mite). Control of the asthmatic condition without adrenal suppression and circadian rhythm alteration. Chronobiologia 4: 295–312Google Scholar
- Reinberg A, Pauchet F, Ruff F, Gervais A, Smolensky M, Levi F, Gervais P, Chaouat D, Abella ML (1986) Once-a-day (morning versus evening) sustained release theophylline in nocturnal asthma. Ann Rev Chronopharmacol 3: 147–150Google Scholar
- Reinberg A, Smolensky M (1983) Biological Rhythms and Medicine. Springer, New York HeidelbergGoogle Scholar
- Smolensky M, Scott PH, Barnes PJ, Jonckman J (1986) The chronopharmacology and chronotherapy of asthma. Ann Rev Chronopharmacol 2: 229–273Google Scholar