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The Mechanisms of Action of Antipsychotics and Antidepressant Drugs

  • Conference paper
Neuroendocrinology of Mood

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 8))

Abstract

The introduction of neuroleptics and tricyclic antidepressant drugs represents a major breakthrough in the treatment of psychiatric disorders. The changes of central monoamine metabolism induced by these psychoactive compounds are still the basis for current theories on the role of the monoamines in the pathophysiol- ogy of psychosis and depression. The depressive disorders have been linked with the functional state of noradrenergic and serotoninergic neurons, schizophrenia mainly with the transmission of dopaminergic neurons. The effects of antipsychotics and antidepressants in psychiatric patients demonstrate the importance of the interplay between basic and clinical science in the understanding and the treatment of psychiatric disorders. The mechanism of action of these two major groups of psychopharmacological drugs will be discussed within a clinical framework.

The work reported here has been supported by the Swedish Medical Research Council (714/85, 5454 and 7027), Karolinska Institute and the Swedish Medical Society

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Authors and Affiliations

  1. Department of Psychiatry and Psychology, Karolinska Institute, Karolinska Hospital, S-104 01, Stockholm, Sweden

    F. A. Wiesel

  2. Department of Psychiatry, University of Lund, University Hospital, S-221 85, Lund, Sweden

    L. Träskman-Bendz

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  1. F. A. Wiesel
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  1. Pharmakologisches Institut, Universität Heidelberg, 1m Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph.D.

  3. Karolinska Institute, P.O. Box 60400, 10401, Stockholm, Sweden

    Kjell Fuxe M.D.

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Wiesel, F.A., Träskman-Bendz, L. (1988). The Mechanisms of Action of Antipsychotics and Antidepressant Drugs. In: Ganten, D., Pfaff, D., Fuxe, K. (eds) Neuroendocrinology of Mood. Current Topics in Neuroendocrinology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72738-2_5

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