Abstract
A reliable technique for a portacaval anastomosis (PCA) in rats was first published by Lee and Fisher 1961. Since then the biological and biochemical consequences have been studied extensively in numerous investigations. The occurrence of a urolithiasis following PCA was first reported by Herz et al. 1972. Disturbances of uric acid metabolism that were caused by the shunt were thought to be responsible. They should lead to an increased production of endogenous uric acid and thus to hyperuricosuria. Investigations that were published since then mainly focused on chemical stone analysis (Bichler et al. 1974; Rasenack et al. 1977; Wallace et al. 1984).
Preview
Unable to display preview. Download preview PDF.
References
Bichler KH, Kirchner Ch, Zelder O (1974) Erhöhung des Harnsäurespiegels im Serum und Urin der Ratte nach portokavalem Shunt. In: Vahlensieck W, Gasser G (eds) Harnsteinsymposium Bonn - Wien. Steinkopff, Darmstadt, pp 109–114
Herz R, Sautter V, Bircher J (1972) Fortuitous discovery of urate nephrolithiasis in rats subjected to portacaval anastomosis. Experientia 28: 27–28
Lee SH, Fisher B (1961) Portacaval shunt in the rat. Surgery 50: 668–672
Linnemann U, Kuch P, SchwĂ¼le PO (1986) Ammonium-urat-urolithiasis in the rat with portacaval shunt — some aspects of mineral metabolism and urine composition. Urol Res 14: 319–322
Rasenack U, GrĂ¼n M, Liehr H (1977) Morphologische Untersuchungen der extrahepatischen Folgen einer portokavalen End-zu-Seit-Anastomose der Ratte. Z Gastroent 15: 457–468
Sanders G, Hesse A (1985) Harnsteine bei Katzen Struvit — Steinbildung ohne Infektion. In: Gasser G, Vahlensieck W (eds) Pathogenese und Klinik der Harnsteine XI. Steinkopff, Darmstadt, pp 326–335
Wallace DMA, Ackermann D, Davis B, Hartmann WH (1984) Uric acid lithiasis and proliferative changes in the rat urinary bladder after portacaval anastomosis. In: Harzmann R, Jacobi GH, WeiĂŸbach L (eds) Experimentelle Urologie. Springer, Berlin Heidelberg New York, pp 430–433
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schramek, P., Engelmann, U., GrĂ¼n, M., Dosch, W., Gemmer, P. (1987). Urolithiasis Following Portacaval Shunt in Rats. In: Jacobi, G.H., RĂ¼bben, H., Harzmann, R. (eds) Investigative Urology 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72735-1_34
Download citation
DOI: https://doi.org/10.1007/978-3-642-72735-1_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72737-5
Online ISBN: 978-3-642-72735-1
eBook Packages: Springer Book Archive