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Alzheimer’s Disease Causes Metabolic Uncoupling of Associative Brain Regions Beyond that Seen in the Healthy Elderly

  • Stanley I. Rapoport
  • Barry Horwitz
  • C. L. Grady
  • J. V. Haxby
Part of the NATO ASI Series book series (volume 9)

Abstract

Alzheimer’s disease (AD) is a progressive degenerative brain disorder that has no agreed-upon cause. The earliest and most prominent neuropsychological deficit is recent memory impairment, which usually is attributed to pathological and neurochemical changes in the hippocampus, amygdala and neocortex (3, 5, 32). The first cognitive deficits to appear that are related to neocortical dysfunction are impairments of attention, abstract reasoning, language and visuospatial construction (18, 20, 21).

Keywords

Alzheimerrs Disease Positron Emission Tomography Alzheimerrs Disease Patient Demented Patient Association Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Stanley I. Rapoport
    • 1
  • Barry Horwitz
    • 1
  • C. L. Grady
    • 1
  • J. V. Haxby
    • 1
  1. 1.Laboratory of Neurosciences National Institute on AgingNational Institutes of HealthBethesdaUSA

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