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Autoimmune Diabetes in the BioBreeding/Worcester Rat

  • Chapter
The Pathology of the Endocrine Pancreas in Diabetes

Abstract

The BioBreeding rat develops a spontaneous diabetic syndrome resembling human type 1 diabetes mellitus. The salient features include: abrupt onset of insulin-dependent, ketosis-prone diabetes between 60–120 days of age [1]; lymphocytic insulitis with virtually complete destruction of the pancreatic B-cells [2, 3]; genetic predisposition and the occurrence of hyperglycemia in approximately 40%–80% of the inbred BioBreeding/Worcester (BB/Wor) colony [4].

Supported in part by USPHS Grant # NIDDK-19155 and Contract # NO1-DK-4-2254

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Authors
  1. A. A. Like
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  2. E. J. Weringer
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Editor information

Editors and Affiliations

  1. Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, B-4000, Liège 1, Belgium

    Pierre J. Lefèbvre

  2. Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium

    Daniel G. Pipeleers

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© 1988 Springer-Verlag Berlin Heidelberg

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Like, A.A., Weringer, E.J. (1988). Autoimmune Diabetes in the BioBreeding/Worcester Rat. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-72691-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72693-4

  • Online ISBN: 978-3-642-72691-0

  • eBook Packages: Springer Book Archive

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