Abstract
In his doctoral thesis Paul Langerhans [55] demonstrated for the first time that the pancreas contains elements other than the exocrine acini. During the subsequent years there was only slow progress in the understanding of the pancreatic islets. The first international symposium on the pancreatic islets was held in Uppsala 1963, and 6 years later the centenary of Paul Langerhans’ discovery was celebrated in Umeå. On the latter occasion it was stated in the opening address [17] that more secrets had been revealed about the pancreatic islets since the first symposium than during the whole of the rest of the century since the discovery of the islets.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The work reported from the author’s laboratory was supported by the Swedish Medical Research Council (12X–562), the Swedish Diabetes Association, and the Nordic Insulin Foundation. The establishment of the patch clamp technique was made possible by donations from the Wallenberg Foundation and the Swedish Council for Planning and Corrdination of Research.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Andersson T, Berggren P-O, Gylfe E, Hellman B (1982) Amounts and distribution of intracellular magnesium and calcium in pancreatic B-cells. Acta Physiol Scand 114: 235–241
Ashcroft SJH, Weerasinghe LCC, Randle PJ (1973) Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochem J 132: 223–231
Ashcroft FM, Harrison DE, Ashcroft SJH (1984) Glucose induces closure of single potassium channels in isolated rat pancreatic B-cells. Nature (London) 312: 446–448
Atwater I, Goncalves A, Herchuelz A, Lebrun P, Malaisse WJ, Rojas E, Scott A (1984) Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets. J Physiol (Lond) 348: 615–627
Bergsten P, Hellman B (1984) Glucose inhibits insulin release when not promoting the entry of Ca2+ into the B-cells. Biochem Biophys Res Commun 125: 875–881
Bergsten P, Rorsman F, Hellman B (1986) Modifications of the pancreatic B-cell function after lowering their potassium content. Acta Physiol Scand 128: 619–628
Bhatena SJ, Awoke S, Voyles NR, Wilkins SD, Recant L, Oie HK, Gazdar AF (1984) Insulin, glucagon and somatostatin secretion by cultured rat islet cell tumor and its clones. Proc Soc Exp Biol Med 175:35–38
Borg LAH, Andersson A (1981) Long-term effects of glibenclamide on the insulin production, oxidative metabolism and quantitative ultrastructure of mouse pancreatic islets maintained in tissue culture at different glucose concentrations. Acta Diabetol Lat 18: 65–83
Charles S, Ketelslegers JM, Buysschaert M, Lambert AE (1981) Hyperglycemic effect of nifedipine. Br Med J 283:19–20
Charles S, Tamagawa T, Henquin JC (1982) A single mechanism for the stimulation of insulin release and 86Rb efflux from rat islets by cationic amino acids. Biochem J 208: 301–308
Colca JR, McDonald JM, Kotagal N, Patke C, Fink J, Greider MH Lacy PE, McDaniel ML (1982) Active calcium uptake by islet-cell endoplasmic reticulum. J Biol Chem 257: 7223–7228
Colca JR, Kotagal N, Lacy PE, McDaniel ML (1983) Modulation of active Ca2+ uptake by the islet-cell endoplasmic reticulum. Biochem J 212:113–121
Cook DL, Hales CN (1984) Intracellular ATP directly blocks K+ channels in pancreatic B-cells. Nature (London) 311: 271–273
Cook DL, Ikeuchi M, Fujimoto WY (1984) Lowering of pH inhibits Ca2+-activated K+ channels in pancreatic B-cells. Nature (London) 311: 269–271
Devis G, Somers G, Malaisse WJ (1975) Stimulation of insulin release by calcium. Biochem Biophys Res Commun 67: 525–529
Efendić S, Enzmann F, Nylén A, Uvnäs-Wallensten K, Luft R (1979) Effect of glucose/sulfonylurea interaction on release of insulin, glucagon and somatostatin from isolated perfused rat pancreas. Proc Natl Acad Sci USA 76: 5901–5904
Falkmer S, Hellman B, Täljedal IB (1970) Opening address. In: Falkmer S, Hellman B and Täljedal IB (eds). The structure and metabolism of the pancreatic islets. A centennial of Paul Langerhans’ discovery. Pergamon, Oxford, p 1
Findlay I, Dunne MJ (1985) Voltage-activated Ca2+ currents in insulin-secreting cells. FEBS Lett 189: 281–285
Findlay I, Dunne MJ, Petersen OH (1985) High-conductance K+ channel in pancreatic islet cells can be activated and inactivated by internal calcium. J Membr Biol 83: 169–175
Findlay I, Dunne MJ, Petersen OH (1985) ATP-sensitive inward rectifier and voltage- and calcium-activated K+ channels in cultured pancreatic islet cells. J Membr Biol 88:165–172
Findlay I, Dunne MJ, Ullrich S, Wollheim CB, Petersen OH (1985) Quinine inhibits Ca2+-independent K+ channels whereas tetraethylammonium inhibits Ca2+-activated K+ channels in insulin-secreting cells. FEBS Lett 185: 4–8
Formby B, Capito K, Egeberg J, Hedeskov CJ (1976) Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets. Am J Physiol 230: 441–448
Ganda OP, Srikanta S, Brink SJ, Morris MA, Gleason RE, Soeldner SJ, Eisenbarth GS (1984) Differential sensitivity to ß-cell secretagogues in “early” type 1 diabetes mellitus. Diabetes 33: 516–521
Gedik O, Zileli MS (1977) Effects of hypocalcemia and theophylline on glucose tolerance and insulin release in human beings. Diabetes 26: 813–819
Gepts W (1957) Contributions à l’étude morphologique des ilots de Langerhans au cours du diabète. Thesis. Editions Acta Med Belg, Bruxelles, pp 1–108
Grodsky GM, Bennett LL (1966) Cation requirements for insulin secretion in the isolated perfused pancreas. Diabetes 15: 910–912
Grunfeld C, Chappell DA (1983) Hypokalemia and diabetes mellitus. Am J Med 75: 553–554
Giugliano D, Torella R, Cacciapuoti F, Gentile S, Verza M, Varriechio M (1980) Impairment of insulin secretion in man by nifedipine. Eur J Clin Pharmacol 18: 395–398
Gylfe E, Hellman B (1986) Glucose-stimulated sequestration of Ca2+ in clonal insulin-releasing cells. Biochem J 233: 865–870
Gylfe E, Hellman B, Sehlin J, Täljedal IB (1984) Interaction of sulfonylurea with the pancreatic ß-cell. Experientia 40:1126–1134
Hellman B (1975) The significance of calcium for glucose stimulation of insulin release. Endocrinology 97: 392–398
Hellman B (1976) Stimulation of insulin release after raising extracellular calcium. FEBS Lett 63:125–128
Hellman B (1982) The mechanism of sulfonylurea stimulation of insulin release. Acta Biol Med Germ 41:1211–1219
Hellman B (1985) ß-cell cytoplasmic Ca2+ balance as a determinant for glucose-stimulated insulin release. Diabetologia 28: 494–501
Hellman B (1986) Calcium transport in pancreatic ß-cells: implications for glucose regulation of insulin release. Diabetes Metab Rev 2: 215–241
Hellman B, Gylfe E (1985) Glucose regulation of insulin release involves intracellular sequestration of calcium. In: Rubin RP, Weiss GB and Putney Jr JW (eds) Calcium in biological systems. Plenum, New York, pp 93–99
Hellman B, Gylfe E (1986) Calcium and the control of insulin secretion. In: Cheung WY (ed) Calcium and cell function, vol 6. Academic, New York, pp 253–326
Hellman B, Gylfe E (1986) Mobilization of different intracellular calcium pools after activation of muscarinic receptors in pancreatic beta-cells. Pharmacology 32: 257–267
Hellman B, Idahl L-Å, Danielsson Å (1969) Adenosine trisphosphate levels in mammalian pancreatic ß-cells after stimulation with glucose and hypoglycemic sulfonylureas. Diabetes 18: 509–516
Hellman B Andersson T, Berggren P-O, Flatt P, Gylfe E, Kohnert K-D (1979) The role of calcium in insulin secretion. In: Dumont J, Nunez J (eds) Hormone and cell regulation, vol 3. Elsevier, Amsterdam, pp 69–96
Hellman B, Andersson T, Berggren P-O, Rorsman P (1980) Calcium and pancreatic ß-cell function. II Modification of 45Ca fluxes by Na+ removal. Biochem Med 24:143–152
Hellman B, Honkanen T, Gylfe E (1982) Glucose inhibits insulin release induced by Na+ mobilization of intracellular calcium. FEBS Lett 148: 289–292
Hellman B, Hällgren R, Abrahamsson H, Bergsten P, Berne C, Gylfe E, Rorsman P, Wide L (1985) The dual action of glucose on the cytosolic Ca2+ activity in pancreatic ß-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man. Biomed Biochim Acta 44: 63–70
Hellman B, Arkhammar P, Berggren P-O, Bergsten P, Gylfe E, Nilsson T, Rorsman F, Rorsman P, Trube G, Wesslén N (1986) Evidence for bidirectional glucose control of the cytoplasmic calcium regulating insulin release. In: Serrano-Rios M, Lefèbvre PJ (eds) Diabetes 1985. Elsevier, Amsterdam, pp 177–180
Hellman B, Gylfe E, Wesslén N (1986) Inositol 1,4,5-trisphosphate mobilizes glucose-incorporated calcium from pancreatic islets. Biochem Int 13: 383–389
Hellman B, Gylfe E, Bergsten P (1987) Mobilization of different pools of glucose-incorporated calcium in pancreatic ß-cells after muscarinic receptor activation. In: Atwater I, Rojas E, Soria B (eds), Biophysics of the pancreatic ß-cell. Plenum, New York, pp 325–341
Henriksson C, Claes G, Gylfe E, Hellman B, Zettergren L (1978) Collagenase isolation and 45Ca efflux studies of human islets of Langerhans. Eur Surg Res 10: 343–351
Herchuelz A, Malaisse WJ (1980) Regulation of calcium fluxes in rat pancreatic islets: dissimilar effects of glucose and of sodium ion accumulation. J Physiol (Lond) 302: 263–280
Herchuelz A, Malaisse WJ (1981) Calcium movements and insulin release in pancreatic islet cells. Diabète Métab 7: 283–288
Hutton JC, Peskavaria M (1982) Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules. Biochem J 204:161–170
Hutton JC, Penn EJ, Peskavaria M (1983) Low-molecular weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J 210: 297–305
Jones PM, Stuchfield J, Howell SL (1985) Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilized by high voltage discharge. FEBS Lett 191: 102–106
Kohnert KD, Hahn HJ, Gylfe E, Borg H, Hellman B (1979) Calcium and pancreatic ß-cell function. 6. Glucose and intracellular 45Ca distribution. Mol Cell Endocrinol 16: 205–220
Krieger-Brauer H, Gratzl M (1982) Uptake of Ca2+ by isolated secretory vesicles from adrenal medulla. Biochim Biophys Acta 691: 61–70
Langerhans P (1869) Beiträge zur mikroskopischen Anatomie der Bauchspeicheldrüse. Thesis, Lange, Berlin, pp 1–32
Leahy JL, Weir GC (1985) Unresponsiveness to glucose in a streptozocin model of diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration. Diabetes 34:653–659
Leahy JL, Cooper HE, Deal DA, Weir GC (1986) Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77: 908–915
MacDonald MJ (1984) The use of calcium uptake by small amounts of mitochondria from pancreatic islets to study mitochondrial respirations. The effects of diazoxide and sodium. Biochem Int 8: 771–778
Marty A, Neher E (1982) Ionic channels in cultured rat pancreatic islet cells. J Physiol (Lond) 326: 36–37P
Matthews EK (1979) Calcium translocation and control mechanisms for endocrine secretion. Symp Soc Exp Biol 33: 225–249
Matteson DR, Armstrong CM (1986) Properties of two types of calcium channels in clonal pituitary cells. J Gen Physiol 87:161–182
Metz SA, Halter JB, Robertson RP (1979) Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus. J Clin Endocrinol Metab 48: 827–835
Milner RDG, Hales CN (1967) The role of calcium and magnesium in insulin secretion from rabbit panreas studied in vitro. Diabetologia 3: 47–49
Pershadsingh HA, McDaniel ML, Landt M, Bry CG, Lacy PE, McDonald JM (1980) Ca2+-activated ATPase and ATP-dependent calmodulin-stimulated Ca2+transport in islet cell plasma membrane. Nature (London) 288: 492–495
Prentki M, Wollheim CB (1984) Cytosolic free Ca2+in insulin secreting cells and its regulation by isolated organelles. Experientia 40:1052–1060
Prentki M, Janjic D, Wollheim CB (1983) The regulation of extramitochondrial steady state free Ca2+ concentration by rat insulinoma mitochondria. J Biol Chem 258: 7597–7602
Robertson RP, Brunzell JD, Hazzard WR, Lerner RL, Porte D Jr (1972) Paradoxical hypoinsulinaemia: an alpha-adrenergic-mediated response to glucose. Lancet 2: 787–789
Rorsman P, Abrahamsson H (1985) Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+. Acta Physiol Scand 125: 639–647
Rorsman P, Hellman B (1987) Voltage-activated currents in guinea-pig pancreatic α2-cells. Evidence for Ca2+-dependent action potentials. J Gen Physiol (in press)
Rorsman P, Trube G (1985) Glucose-dependent K+-channels in panreatie ß-cells are regulated by intracellular ATP. Pflugers Arch 405: 305–309
Rorsman P, Trube G (1986) Calcium and delayed potassium currents in mouse pancreatic ß-cells under voltage-clamp conditions. J Physiol (Lond) 374: 531:-550
Rorsman P, Berggren P-O, Gylfe E, Hellman B (1983) Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose. Biosci Rep 3: 939–946
Rorsman P, Abrahamsson H, Gylfe E, Hellman B (1984) Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic B-cells. FEBS Lett 170:196–200
Rorsman P, Arkhammar P, Berggren P-O (1986) Voltage-activated Na+ currents and their suppression by phorbol ester in the clonal insulin-producing cell line RINm5F. Am J Physiol 251, C912-C919
Röjdmark S, Andersson DEH (1984) Influence of verapamil on glucose tolerance. Acta Med Scand [Suppl] 681: 37–42
Satin LS, Cook DL (1985) Voltage-gated Ca2+ current in pancreatic ß-cells. Pflugers Arch 404: 385–387
Seltzer HS, Crout JR (1968) Insulin secretory blockade by benzothiadiazines and catecholamines: reversal by sulfonylureas. Ann NY Acad Sci 150: 309–321
Sturgess NC, Ashford MLJ, Cook DL, Hales CN (1985) The sulphonylurea receptor may be an ATP-sensitive potassium channel. Lancet 8453: 474–475
Tamagawa T, Niki H, Niki A (1985) Insulin release independent of a rise in cytosolic free Ca2+by forskolin and phorbol ester. FEBS Lett 183: 430–432
Trube G, Ohno-Shosaku T, Rorsman P, Zünkler BJ (1986) Hypoglycemic sulfonylureas inhibit ATP-dependent K channels in pancreatic B-cells. Pflugers Arch 406: R63
Trube G, Rorsman P, Ohno-Shosaku T (1986) Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ß-cells. Pflugers Arch 407:493–499
Wesslén N, Hellman B (1986) The influx of Ca2+ into pancreatic ß-cells and its regulation by glucose. Biomed Res 7: 339–344
Wollheim CB, Pozzan T (1984) Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line. J Biol Chem 259: 2262–2267
Wollheim CB, Sharp GWG (1981) Regulation of insulin release by calcium. Physiol Rev 61: 914–973
Wollheim CB, Ullrich S, Pozzan T (1984) Glyceraldehyde but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+. FEBS Lett 177:17–22
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hellman, B. (1988). Calcium Transport and Deficient Insulin Release. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-72691-0_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72693-4
Online ISBN: 978-3-642-72691-0
eBook Packages: Springer Book Archive