Abstract
The human endocrine pancreas is composed of four major cell types, A-, B-, D-, and PP-cells, which are distinguished by routine staining procedures, immuno-cytochemistry and electron microscopy. The A-cells secrete glucagon and contain round and dense granules. The B-cells produce insulin. They make up the core of the islet and are characterized by the presence of rectangular insulin-containing granules. The D-cells, which are responsible for the secretion of somatostatin, contain large and pale granules. PP-cells produce pancreatic polypeptide (PP) and have dark and small granules [91, 109, 110, 111]. The PP-cells, but not the other endocrine cell types, have also been reported to be scattered within the exocrine pancreas [87].
Keywords
- Islet Cell
- Vasoactive Intestinal Peptide
- Pancreatic Polypeptide
- Pancreatic Islet Cell
- Islet Cell Hormone
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Somers, G., De Vroede, M. (1988). Islet Cell Tumors and Diabetes Mellitus. In: Lefèbvre, P.J., Pipeleers, D.G. (eds) The Pathology of the Endocrine Pancreas in Diabetes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72691-0_10
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