Mononitrate II pp 167-177 | Cite as

Differential Effects of Nitrates and Calcium Antagonists on the Coronary Vasculature in Conscious Patients

  • C. J. Pepine
  • R. L. Feldman
  • C. R. Lambert
  • J. A. Hill
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)


Both nitrates and calcium antagonists are clearly beneficial in patients with ischemic heart disease. The precise mechanisms responsible for these favorable actions, however, are not completely understood. Both classes of drugs reduce myocardial oxygen demand and have been suggested to produce important actions on the coronary circulation [1–3]. This suggestion is based upon extensive animal experimentation and studies of patients with coronary artery spasm. But extrapolation from animal studies to patients with coronary artery disease (CAD) is always difficult and patients with coronary spasm are not the same as those with chronic effort angina in whom these agents are more frequently used. Furthermore, certain clinical situations may dictate use of a nitrate rather than a calcium antagonist or vice versa and the drugs may be used in combination. So determination of the similarities and differences of the coronary vascular effects of these agents could be of clinical importance.


Leave Anterior Descend Aortic Pressure Left Ventricular Filling Pressure Epicardial Coronary Artery Myocardial Oxygen Demand 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • C. J. Pepine
  • R. L. Feldman
  • C. R. Lambert
  • J. A. Hill

There are no affiliations available

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