Pharmacodynamics of Organic Nitrates — In Vitro and In Vivo Studies
The mechanism of vasodilation and a hypothesis for the mechanism of tolerance development
Whether there is a general correlation between pharmacokinetics (denitration), and pharmacodynamics (relaxation of vascular smooth muscle), of organic nitrates
The dose — response curve of isosorbide 5-mononitrate (IS-5-MN) in a conscious dog model of coronary heart disease
KeywordsNitrous Oxide Vascular Smooth Muscle Cell cGMP Level Cyclic Guanosine Monophosphate Isosorbide Dinitrate
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- 3.Müller-Beckmann B, Hom S, Bartsch W, Strein K, Böhm E (1984) Isosorbide-5-mononitrate increases cyclic guanosine monophosphate levels in rat aorta. IRCS Med Sci 1: 713–714Google Scholar