EEG Mapping in Pathological Aging and Dementia: Utility for Diagnosis and Therapeutic Evaluation

  • B. Gueguen
  • P. Etevenon
  • D. Plancon
  • J. Gaches
  • J. De Recondo
  • P. Rondot
Conference paper

Abstract

Quantified EEG (Remond 1961; Drohocki 1968; Walter and Brazier 1968; Dolce and Kunkel 1975; Etevenon 1977) and mapping (Lehmann 1971; Ragot and Remond 1978; Duffy et al. 1981; Buehsbaum etal. 1982) have allowed more precise and reliable EEG analysis than visual methods. However, while the place of these methods in daily clinical practice is being debated they are giving rise to an excess of pictorial and numerical data. Much work has been published concerning aging and dementia (Duffy et al. 1984 a, b; Coben et al. 1985; Penttila etal. 1985; Gueguen etal. 1986; Senant etal. 1986), but only a few studies in the past 2 years have really used EEG as a tool for diagnosis or for therapeutic evaluation (Cutler et al. 1985; Little et al. 1985; Bruno et al. 1986; Delwaïe et al. 1986; Partanen et al. 1986; Schwartz and Kolstaedt 1986). EEG changes occur early in dementia and are well correlated with the stage of cognitive impairment (Coben etal. 1985; Penttila etal. 1985). We report here preliminary results concerning the usefulness of quantified EEG methods in diagnosis and treatment of pathological aging.

Keywords

Placebo Depression Dementia Neurol Lecithin 

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References

  1. Bondareff W (1983) Age and Alzheimer’s disease. Lancet 1447Google Scholar
  2. Bruno G, Mohr E, Gillespie M, Fedio P, Chase TN (1986) Muscarinic agonist therapy in Alzheimer’s disease. Arch Neurol 43:659–661PubMedCrossRefGoogle Scholar
  3. Buchsbaum MS, Rigal F, Coppola R, Cappeletti J, King C, Johnson J (1982) A new system for gray-level surface distribution maps of electrical activity. Electroencephalogr Clin Neurophysiol 53:237–242PubMedCrossRefGoogle Scholar
  4. Coben AL, Danziger W, Storandt M (1985) A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. Electroencephalogr Clin Neurophysiol 61:101–112PubMedCrossRefGoogle Scholar
  5. Cutler NR, Haxby J, Kay AD, Narang PK, Lesko LJ, Costa JL, Ninos M, Linnoila M, Potter WZ, Renfrew JW, Moore AM (1985) Evaluation of Zimeldine in Alzheimer’s disease. Arch Neurol 42:744–748PubMedCrossRefGoogle Scholar
  6. Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M (1986) Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand 73:136–140PubMedCrossRefGoogle Scholar
  7. Dolce G, Kunkel H (1975) CEAN-Computerized EEG Analysis. Fischer, Stuttgart Drohocki Z (1968) Quantitative electroencephalography: history, methods, applications. Electroencephalogr Clin Neurophysiol 25:303Google Scholar
  8. Duffy FH, Bartels P, Burchfield JL (1981) Significance probability mapping: an aid in the topographic analysis of brain electrical activity. Electroencephalogr Clin Neurophysiol 51:455–462PubMedCrossRefGoogle Scholar
  9. Duffy FH, Albert MS, McAnulty G, Garvery J (1984 a) Age related differences in brain electrical activity in healthy subjects. Ann Neurol 16:430–438PubMedCrossRefGoogle Scholar
  10. Duffy FH, Albert MS, McAnulty G (1984b) Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type. Ann Neurol 16:439–148PubMedCrossRefGoogle Scholar
  11. Etevenon P (1977) Electroencephalographie sur ordinateur (analyse quantitative et statistique). Thèse de Doctorat, Factulte des Sciences, Paris.Google Scholar
  12. Fink M (1974) EEG application in psychopharmacology. Psychopharmacol Agents 111:pp 159–174Google Scholar
  13. Gueguen B, Kobrzynska E, Rondot P, Etevenon P, De Recondo J, Gaches J (1986) EEG cartography as an aid for early detection of dementia in the elderly. In: Senile dementias: early detection. Bes A, Cahn J, Cahn R, Hoyer S, Marc-Vergnes JP, Wisniewski HM (eds) Libbey, Paris, pp 165–170Google Scholar
  14. Hughes JR, Cayaffa JJ (1977) The EEG in patients at different ages without organic cerebral disease. Electroencephalogr Clin Neurophysiol 42:776–784PubMedCrossRefGoogle Scholar
  15. Itil TM (1974) Quantitative pharmaco-electroencephalography. Mod Probl Pharmacopsychiatry 8:43–75Google Scholar
  16. Lehmann D (1971) Multichannel topography of human alpha EEG fields. Electroencephalogr Clin Neurophysiol 31:439–449PubMedCrossRefGoogle Scholar
  17. Little A, Levy R, Chuaqui-Kidd P, Hand D (1985) A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 48:736–742PubMedCrossRefGoogle Scholar
  18. Matejcez M (1979) Pharmaco-encephalography: the value of quantified EEG. Psychopharmacol Pharmacopsychiatr 12:126–136Google Scholar
  19. Partanen JY, Soininen H, Riekkinen PJ (1986) Does an ACTH derivative (org 2766) prevent deterioration of EEG in Alzheimer’s disease? Electroencephalogr Clin Neurophysiol 63:547–551PubMedCrossRefGoogle Scholar
  20. Penttila M, Partanen JW, Soininen H, Riekkinen PJ (1985) Quantitative analysis of occipital EEG in different stages of Alzheimer’s disease. Electroencephalogr Clin Neurophysiol 60:1–6PubMedCrossRefGoogle Scholar
  21. Ragot RA, Remond A (1978) EEG field mapping. Electroencephalogr Clin Neurophysiol 45:417–421PubMedCrossRefGoogle Scholar
  22. Reisberg B, Ferris SH, De Leon MJ, Crook TH (1982) The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry 139(9): 1136–1139PubMedGoogle Scholar
  23. Remond A (1961) Integrated and topological analysis of the EEG. Electroencephalogr Clin Neurophysiol [Suppl] 20:64–67Google Scholar
  24. Rossor MN, Juersen LL, Reynolds GP, Mountjoy CQ, Roth M (1984) Neurochemical characteristics of early and late onset Alzheimer’s disease. Br Med J [Clin Res] 288:961–1064CrossRefGoogle Scholar
  25. Schwartz SA, Kohlstaedt EV (1986) Physostigmine effects in Alzheimer’s disease. Relationship to dementia severity. Life Sci 38:1021–1028PubMedCrossRefGoogle Scholar
  26. Senant J, Samson-Dollfus D, Delapierre G, Menard JF, Bertoldi-Lefever I (1986) Analyse automatique de l’EEG et vieillissement chez les sujets normaux et vasculaires. Sem Hop Paris 44:3505–3509Google Scholar
  27. Walter DO, Brazier AB (1968) Advances in EEG analysis. Electroencephalogr Clin Neurophysiol [Suppl] 27:1–75Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. Gueguen
    • 1
  • P. Etevenon
    • 1
  • D. Plancon
    • 1
  • J. Gaches
    • 1
  • J. De Recondo
    • 2
  • P. Rondot
    • 2
  1. 1.Department of Clinical NeurophysiologySainte-Anne HospitalParis Cedex 14France
  2. 2.Department of NeurologySainte-Anne HospitalParis Cedex 14France

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