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Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis pp 429–438Cite as

Standards for the Assay of Erythropoietin

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Part of the book series: NATO ASI Series ((ASIH,volume 8))

Summary

The advent of rDNA-derived erythropoietin, in addition to making reagents available for immunoassays, might improve their accuracy by providing standards consisting of purified hormone. But since glycoprotein hormones exist in different forms, it may not be possible to obtain a standard of purified hormone which is identical to that in the specimens for assay. Furthermore, a glycoprotein hormone prepared by present-day rDNA procedures is likely to differ from the native hormone in its carbohydrate structure. However, WHO is establishing an international standard of an rDNA-derived analogue of erythropoietin for use in the bioassay control of therapeutic products, and this standard will also be studied for its suitability in immunoassays.

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Author information

Authors and Affiliations

  1. Division of Hormones, National Institute for Biological Standards and Control (WHO International Laboratory for Biological Standards), Holly Hill, UK

    Patrick L. Storring

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  1. Patrick L. Storring
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Editor information

Editors and Affiliations

  1. Abteilung für Transfusionsmedizin, Universität Ulm DRK Blutspendezentrale, Oberer Eselsberg 10, 7900, Ulm, Germany

    Ivan N. Rich

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© 1987 Springer-Verlag Berlin Heidelberg

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Storring, P.L. (1987). Standards for the Assay of Erythropoietin. In: Rich, I.N. (eds) Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis. NATO ASI Series, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72652-1_32

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  • DOI: https://doi.org/10.1007/978-3-642-72652-1_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72654-5

  • Online ISBN: 978-3-642-72652-1

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