Abstract
Association of cancer with transplantation may be seen in three situations:
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1.
The graft recipient is prone to development of de novo malignancies as a consequence of immunosuppression.
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2.
Patients who have been treated previously for cancer may plan to undergo transplantation (tumor patient as graft recipient). In this situtation the question arises whether or not the subsequent immunosuppression would promote tumor recurrence.
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3.
Malignancies arising in the organ itself or metastatically from other sites may be transplanted accidentally with the homograft (tumor patient as organ donor).
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References
Beveridge T, Krupp P, McKibbin C (1984) Lymphomas and lymphoproliferative lesions developing under cyclosporine therapy. Lancet 1: 788
Bia MJ, Flye MW (1985) Immunoblastic lymphoma in a cyclos- porine-treated renal transplant recipient. Transplantation 39: 673–675
Birkeland SA (1983 a) Malignant tumors in renal transplant patients. Cancer 51: 1571–1575
Birkeland SA (1983 b) Cancer in cadaver kidney transplant patients. Surgery 93: 504–509
Blohmé I, Brynger H (1985) Malignant disease in renal transplant patients. Transplantation 39: 23–25
Blohmé I, Larkö O (1984) Premalignant and malignant skin lesions in renal transplant patients. Transplantation 37: 165–167
Boyle J, Briggs JD, MacKie RM, Junor BJR, Aitchison TC (1984) Cancer, warts, and sunshine in renal transplant patients. A case-control study. Lancet 1: 702–704
Burnet FM (1971) Immunological surveillance in neoplasia. Transplant Rev 7: 3–25
Calne RY, Rolles K, Thiru S, McMaster P, Craddock GN, Aziz S, White DJG, Evans DB, Dunn DC, Henderson RG, Lewis P (1979) Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. Lancet 2: 1033–1036
Dossetor JB, Kovithavongs T, Salkie M, Preiksaitis J (1984) Cyclosporine-associated lymphoproliferation, despite controlled cyclosporine blood concentrations, in a renal allograft recipient. Proc EDTA-ERA 21: 1021–1026
Editorial (1983) Cyclosporin and neoplasia. Lancet 1: 1083
Geis WP, Iwatsuki S, Molnar Z, Giacchino JL, Kerman RH, Ing TS, Hano JE (1978) Pseudolymphoma in renal allograft recipients. Arch Surg 113: 461–466
Gokel JM, Rjosk HK, Meister P, Stelter WJ, Witte J (1977) Metastatic choriocarcinoma transplanted with cadaver kidney. A case report. Cancer 39: 1317–1321
Greene MH, Young TL, Clark WH (1981) Malignant melanoma in renal-transplant recipients. Lancet 1: 1196–1198
Hardiel P, Strong RW, Hartley LCJ, Woodruff PWH, Clunie GJA (1980) Skin cancer in Caucasian renal allograft recipients living in a subtropical climate. Surgery 87:177–183
Jacobs C, Brunner FP, Brynger H, Chantler C, Donckerwolcke RA, Hathway RA, Kramer P, Selwood NH, Wing AJ (1981) Malignant diseases in patients treated by dialysis and transplantation in Europe, Transplant Proc 13: 729–732
Jamieson NV, Thiru S, Calne RY, Evans DB (1981) Gastric lymphomas arising in two patients with renal allografts. Transplantation 31: 224–225
Kinlen LJ (1985) Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. Am J Med 78: 44–49
Kinlen LJ, Sheil AGR, Peto J, Doll R (1979) Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs. Br Med J 2: 1461–1466
Klein G (1972) Herpes virus and oncogenesis. Proc Natl Acad Sci USA 69: 1056–1064
Klein G (1975) The Epstein-Barr virus and neoplasia. N Engl J Med 293: 1353–1357
Koranda FC, Dehmel EM, Kahn G, Penn I (1974) Cutaneous complications in immunosuppressed renal homograft recipients. JAMA 229: 419–424
Kramer P, Broyer M, Brunner FP, Brynger H, Challah S, Oules R, Rizzoni G, Selwood NH, Wing AJ, Balás EA (1984) Combined report on regular dialysis and transplantation in Europe, XIV, 1983. Proc EDTA-ERA 21: 47–50
Krueger TC, Tallent MB, Richie RE, Johnson HK, MacDo-nell RC, Turner B (1985) Neoplasia in immunosuppressed renal transplant patients: a 20-year experience. South Med J 78:501–505
Krupp P, Gülich A, Timonen P (1986) Treatment with cyclosporine, combination therapy. Side effects and safety of San-dimmun in long-term treatment of renal transplant patients. Transplant Proc 18: 991–992
Matas AJ, Simmons RL, Kjellstrand CM, Buselmeier TJ, Najarian JS (1975) Increased incidence of malignancy during chronic renal failure. Lancet 1: 883–885
Miach PJ, Dawborn JK, Xipell J (1976) Neoplasia in patients with chronic renal failure on long-term dialysis. Clin Nephrol 5:101–104
O’Neill FJ, Miles CP (1969) Chromosome changes in human cells induced by herpes simplex, Types 1 and 2. Nature 223: 851–852
Ono Y, Ohshima S, Hanai S, Sugiyama S, Kano T, Suenaga M (1984) A kidney transplant patient with hepatocellular carcinoma. Transplantation 37: 620–621
Penn I (1977) Transplantation in patients with primary renal malignancies. Transplantation 24: 424–434
Penn I (1978) Malignancies associated with immunosuppressive or cytotoxic therapy. Surgery 83: 492–502
Penn I (1981 a) Depressed immunity and the development of cancer. Clin Exp Immunol 46: 459–474
Penn I (1981 b) Malignant lymphomas in organ transplant recipients. Transplant Proc 13: 736–738
Penn I (1983 a) Kaposi’s sarcoma in immunosuppressed patients. J Clin Lab Immunol 12: 1–10
Penn I (1983 b) Renal transplantation in patients with preexisting malignancies. Transplant Proc 15: 1079–1082
Penn I (1984) Cancer in immunosuppressed patients. Transplant Proc 16: 492–494
Penn I (1986) Cancers of the anogenital region in renal transplant recipients. Cancer 58: 611–616
Penn I, First MR (1986) Development and incidence of cancer following cyclosporine therapy. Transplant Proc 18: 210–213
Peters MS, Stuard ID (1978) Metastatic malignant melanoma transplanted via a renal homograft. A case report. Cancer 41: 2426–2430
Rubin RH, Tolkoff-Rubin NE (1982) Viral infection in the renal transplant patient. Proc EDTA 19: 513–526
Shah KH, Lewis MG, Jenson AB, Kurman RJ, Lancester WD (1980) Papillomavirus and cervical dysplasia. Lancet 2:1190
Sheil AGR (1986) Cancer after transplantation. World J Surg 10: 389–396
Sheil AGR, Mahoney JF, Horvath JS, Johnson JR, Tiller DJ, May J, Stewart JH (1979) Cancer and survival after cadaveric donor renal transplantation. Transplant Proc 11: 1052–1054
Siemensen H, Schlamp R, Tachezy H, Bischoff K, Remmecke J (1984) Überlebenszeit und Todesursachen bei Dia-lysepatienten. Dtsch Med Wochenschr 109: 1833–1836
Slifkin RF, Goldberg J, Neff S, Baez A, Matto N, Gupta S (1977) Malignancy in end-stage renal disease. Trans Am Soc Artif Intern Organs 23: 34–39
Sodomann CP, Gropp C (1979) Wie groß ist die Malignomgefahr durch Immunsuppressiva? Internist 20: 571–584
Starzl TE, Porter KA, Iwatsuki S, Rosenthal JT, Shaw BW, Atchison RW, Nalesnik MA, Ho M, Griffith BP, Hakala TR, Hardesty RL, Jaffe R (1984) Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1: 583–587
Sweny P, Farrington K, Younis F, Varghese Z, Baillod RA, Fernando ON, Moorhead JF (1981) Sixteen months experience with cyclosporin-A in human kidney transplantation. Transplant Proc 13: 365–367
Washer GF, Schroter GPJ, Starzl TE, Weil R (1983) Causes of death after kidney transplantation. JAMA 250: 49–54
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Pichlmaier, H., Grundmann, R. (1989). Transplantation and Cancer. In: Veronesi, U., Arnesjø, B., Burn, I., Denis, L., Mazzeo, F. (eds) Surgical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72646-0_21
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DOI: https://doi.org/10.1007/978-3-642-72646-0_21
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