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Estrogens and Bile Secretion

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Assessment and Management of Hepatobiliary Disease

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Abstract

The purpose of this report is to present an overview of the influence of natural and synthetic estrogen on the bile-secreting apparatus. Estrogen-induced alterations of hepatobiliary function range from modifications of bile lipid composition, so that bile becomes supersaturated with cholesterol, to bile flow impairment, i. e., intrahepatic cholestasis (Kern et al. 1978). Most of the knowledge regarding estrogen-induced liver dysfunction has been obtained from experiments focusing on estrogen treatment of animals as well as from clinical experience of estrogen hepatotoxicity in pregnant women and in subjects receiving drugs containing these hormones (Strieker and Spoelstra 1985). The mechanism(s) whereby estrogens interfere with bile secretion is still unknown.

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Author information

Authors and Affiliations

  1. Institute of Medical Pathology, University of Trieste, Trieste, Italy

    M. Frezza & G. Pozzato

  2. Third Medical Clinic, University of Milan School of Medicine, Milan, Italy

    C. Di Padova

Authors
  1. M. Frezza
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  2. G. Pozzato
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  3. C. Di Padova
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Editor information

Editors and Affiliations

  1. Institute of Internal Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy

    Lajos Okolicsányi M.D. (Professor) & Gaetano Crepaldi M.D. (Professor, Director) (Professor) &  (Professor, Director)

  2. Department of Clinical Research, Heimhuder Straße 46, 2000, Hamburg/13, Germany

    Géza Csomós M.D. (Professor) (Professor)

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© 1987 Springer-Verlag Heidelberg

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Frezza, M., Pozzato, G., Di Padova, C. (1987). Estrogens and Bile Secretion. In: Okolicsányi, L., Csomós, G., Crepaldi, G. (eds) Assessment and Management of Hepatobiliary Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72631-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-72631-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72633-0

  • Online ISBN: 978-3-642-72631-6

  • eBook Packages: Springer Book Archive

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