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Antiviral Treatment of Chronic Hepatitis

  • Conference paper
Assessment and Management of Hepatobiliary Disease

  • 112 Accesses

Abstract

Viral hepatitis is a common, worldwide problem. It can to a large extent be prevented by strict hygienic measures, and the risk of transmission in certain subgroups of the population can be minimized because potentially infective material such as blood and blood products can be screened for the presence of HBsAg. Passive immunization is of value in some instances. Active immunization against hepatitis B is obviously a major preventive advance, and hopefully we will eventually have effective vaccines against hepatitis A and the other types of viral hepatitis.

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References

  • Aldershville J, Dietrichson O, Skinhoj P, Mathiesen LR, Christoffersen P, Nielsen JO (1982) Chronic persistent hepatitis: serological classification and meaning of the hepatitis Be system. Hepatology 2: 243–246

    Article  Google Scholar 

  • Alexander G, Williams R (1986) Antiviral treatment in chronic infection with hepatitis B. Br Med J 292: 292–294

    Article  Google Scholar 

  • Anderson MG, Murray-Lyon IM (1985) Natural history of the HBg carrier. Gut 26: 848–860

    Article  PubMed  CAS  Google Scholar 

  • Billiau A (1986) The mode of action of interferons in viral infections and their possible role in the control of hepatitis B. J Hepatol (in press)

    Google Scholar 

  • Chadwick RG, Galizzi J, Heathcote J, Lyssiotis T, Cohen BJ, Scheuer PJ, Sherlock S (1979) Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up. Gut 20: 372–377

    Google Scholar 

  • Cook GC, Mulligan R, Sherlock S (1971) Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Q J Med 40:159–185

    PubMed  CAS  Google Scholar 

  • Fattovich G, Rugge M, Brollo L, Pontisso P, Noventa F, Guido M, Alberti A, Realdi (1986) Clinical, virological and histologic outcome following seroconversion from HBg to Anti-HBe in chronic hepatitis type B. Hepatology 6: 167–172

    Article  PubMed  CAS  Google Scholar 

  • Greenberg HB, Pollard RB, Lutwick LI, Gregory PB, Robinson WS, Merigan TC (1976) Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med 295: 517–522

    Article  PubMed  CAS  Google Scholar 

  • Hoofnagle JH, Davis GL, Hanson RG (1983) Chronic type B hepatitis: clinical course. In: Verme G, Bonino F, Rizzetto (eds) Viral hepatitis and delta infection. Liss, New York, pp 41–53

    Google Scholar 

  • Koretz RL, Lewin CJ, Rebhun DJ, Gitnick G (1978) Hepatitis B surface antigen carriers — to biopsy or not to biopsy. Gastroenterology 83: 860–863

    Google Scholar 

  • Lam KC, Lai CL, Ng RP, Trepo C, Wu PC (1981) Deleterious effect of prednisolone in HBg positive chronic active hepatitis. N Engl J Med 304: 380–386

    Article  PubMed  CAS  Google Scholar 

  • Liaw YF, Chu CM, Chen TJ, Lin DY, Chang-Chien CS, Wu CS (1982) Chronic lobular hepatitis: a clinicopathological and prognostic study. Hepatology 2: 256–261

    Google Scholar 

  • Lok ASF, Lai CL, Wu PC (1986) Spontaneous and interferon induced HBe antigen to antibody seroconversion in chronic hepatitis B virus infection in Hong Kong Chinese. J Hepatol (in press)

    Google Scholar 

  • Novick DM, Lok ASF, Thomas HC (1984) Diminished responsiveness of homosexual men to antiviral therapy for HBg positive chronic liver disease. J Hepatol 1: 29–35

    Google Scholar 

  • Nowicki MJ, Tong MJ, Nair PV, Stevenson D (1984) Detection of anti-HBc I following prednisolone treatment in patients with chronic active hepatitis B virus infection. Hepatology 4: 1129–1133

    Article  PubMed  CAS  Google Scholar 

  • Ornata M (1986) In vivo study on mechanism of action of interferon and ARA-A against HBV and DHBV replication in the liver. J Hepatol (in press)

    Google Scholar 

  • Perrillo R, Regenstein F, Bodicky C, Campbell CR, Sanders GE, Sunwoo YC (1985) Comparative efficacy of adenine arabinoside 5’monophosphate and prednisolone withdrawal followed by adenine arabinoside 5’monophosphate in the treatment of chronic active hepatitis B. Gastroenterology 89: 780–786

    Google Scholar 

  • Pignatelli M, Waters J, Brown D, Lever A, Schaff Z, Gerety R, Thomas H (1986) HLA class I antigens on the hepatocyte membrane during recovery from acute hepatitis B infection and during interferon therapy in chronic HBV infection. Hepatology (in press)

    Google Scholar 

  • Realdi G, Alberti A, Rugge M, Bortolotti F, Rigoli AM, Tremolada F, Ruol A (1980) Seroconversion from hepatitis Be antigen to anti-HBe in chronic hepatitis B infection. Gastroenterology 79:195–199

    PubMed  CAS  Google Scholar 

  • Rosina F, Saracco G, Actis GC, Brunetto MR, Maran E, Pintus C, Dianzani F, Verme G, Rizzetto M, Bonino F (1986) Treatment of chronic delta hepatitis with alpha-2 recombinant interferon (Abstr). Gastroenterology 90: 1762

    Google Scholar 

  • Sagnelli E, Piccinino F, Manzillo G, Felaco FM, Filippini P, Maio G, Pasquale G, Izzo CM (1983) Effect of immunosuppressive therapy on HBg-positive chronic active hepatitis in relation to presence or absence of HBg and Anti-HBe. Hepatology 3: 690–695

    Article  PubMed  CAS  Google Scholar 

  • Sanchez-Tapias JM, Vilar JH, Costa J, Bruguera M, Ballesta AM, Rodes J (1984) Natural history of chronic hepatitis B: relationship between hepatitis B replication and the course of the disease. J Hepatol 1: 15–27

    Article  Google Scholar 

  • Schalm SW, Summerskill WJH, Gitnick GL, Elveback LR (1976) Contrasting features and responses to treatment of severe chronic active liver disease with and without hepatitis Bs antigen. Gut 17: 781–786

    Article  PubMed  CAS  Google Scholar 

  • Schalm SW, Heytink RA, Van Buuren HR, De Man RA (1985) Acyclovir enhances the antiviral effect of interferon in chronic hepatitis B. Lancet II: 358–360

    Article  Google Scholar 

  • Scullard GH, Pollard RB, Smith JL, Sacks SL, Gregory PB, Robinson WS, Merigan TC (1981) Antiviral treatment of chronic hepatitis B virus infection. Changes in viral markers with interferon combined adenine arabinoside. J Infect Dis 143: 772–773

    Article  PubMed  CAS  Google Scholar 

  • Scullard GH, Greenberg HB, Smith JL, Gregory PB, Merigan TC, Robinson WS (1982) Antiviral treatment of chronic hepatitis B virus infection: infectious virus cannot be detected in patient serum after permanent responses to treatment. Hepatology 2: 39–49

    Article  PubMed  CAS  Google Scholar 

  • Soloway RD, Summerskill WHJ, Baggenstoss AH, Geal MG, Gitnick GL, Elveback LR, Schoenfield LJ (1972) Clinical, biochemical and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology 63: 820–833

    PubMed  CAS  Google Scholar 

  • Taylor-Papadimitriou J (ed) (1985) Interferons: their impact in biology and medicine. Oxford University Press, Oxford

    Google Scholar 

  • Thomas HC, Lever AML, Scully LJ, Pignatelli M (1986) Approaches to the treatment of hepatitis B and delta-related liver disease. Semin Liver Dis 6: 34–41

    Article  PubMed  CAS  Google Scholar 

  • Tsiquaye KN, Collins P, Zuckerman AJ (1986) Screening of antiviral agents for treatment of hepatitis B. J Hepatol (in press)

    Google Scholar 

  • Weissberg JI, Andres LL, Smith CI, Weick S, Nichols JE, Garcia G, Robinson WS, Merigan TC, Gregory PB (1984) Survival in chronic hepatitis B: an analysis of 379 patients. Ann Intern Med 101:613–616

    PubMed  CAS  Google Scholar 

  • Weller IVD, Bassendine MF, Murray AK, Craxi A, Thomas HC, Sherlock S (1982) Effects of prednisolone/azathioprine in chronic hepatitis B infection. Gut 23: 650–655

    Article  PubMed  CAS  Google Scholar 

  • Yokosuka O, Ornata M, Imazeki F, Hirota K, Mori J, Uchiumi K, Ito Y, Okuda K (1985) Combination of short-term prednisolone and adenine arabinoside in the treatment of chronic hepatitis B. Gastroenterology 89: 246–251

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Academic Department of Medicine, Royal Free Hospital and School of Medicine, Pond Street, NW3 2QG, London, UK

    Neil McIntyre

Authors
  1. Neil McIntyre
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Editor information

Editors and Affiliations

  1. Institute of Internal Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy

    Lajos Okolicsányi M.D. (Professor) & Gaetano Crepaldi M.D. (Professor, Director) (Professor) &  (Professor, Director)

  2. Department of Clinical Research, Heimhuder Straße 46, 2000, Hamburg/13, Germany

    Géza Csomós M.D. (Professor) (Professor)

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© 1987 Springer-Verlag Heidelberg

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McIntyre, N. (1987). Antiviral Treatment of Chronic Hepatitis. In: Okolicsányi, L., Csomós, G., Crepaldi, G. (eds) Assessment and Management of Hepatobiliary Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72631-6_44

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  • DOI: https://doi.org/10.1007/978-3-642-72631-6_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72633-0

  • Online ISBN: 978-3-642-72631-6

  • eBook Packages: Springer Book Archive

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