Modelling of Malignant Lymphoma in Rabbits, Using Oncogenic Viruses of Non-Human Primates
The discovery of lymphoid B-lymphotropic herpesvirus-producing cell lines from M. arctoides peripheral lymphocytes (MAL-1) producing their own lymphotropic virus HVMA was reported earlier . Subsequently, two more M. arctoides virus-producing lymphoid cell lines (MAL-2, MAL-3) were discovered in our laboratory. The cells of some baboon lymphoid cultures, parallel with B-lymphotropic herpesvirus, produced C-type retrovirus antigenically similar to human T-lymphotropic virus (HTLV)-I. The cells of MAL-1, MAL-2 and MAL-3 cultures also produced B-lymphotropic herpesvirus, and small amounts of retrovirus particles were revealed (Fig. 1). Furthermore, it was reported that a number of Old World monkeys, including M. arctoides, can be the carriers of simian T-lymphotropic virus (STLV) related to HTLV-I .
KeywordsLymphoma Leukemia Eosin Fluorescein Isothiocyanate
Unable to display preview. Download preview PDF.
- 1.Lapin BA, Timanovskaya W, Yakovleva LA (1985) Herpesvirus HVMA: a new representative in the group of the EBV-like B-lympho-tropic herpesviruses of primates. In: Neth R et al. (eds) Modern trends in human leukemia VI. Springer, Berlin Heidelberg New York Tokyo, pp 312–313 (Haematology and blood transfusion, vol 29)Google Scholar