Modelling of Malignant Lymphoma in Rabbits, Using Oncogenic Viruses of Non-Human Primates

  • L. A. Yakovleva
  • V. V. Timanovskaya
  • A. F. Voevodin
  • L. V. Indzhiia
  • B. A. Lapin
  • M. T. Ivanov
  • D. S. Markaryan
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

The discovery of lymphoid B-lymphotropic herpesvirus-producing cell lines from M. arctoides peripheral lymphocytes (MAL-1) producing their own lymphotropic virus HVMA was reported earlier [1]. Subsequently, two more M. arctoides virus-producing lymphoid cell lines (MAL-2, MAL-3) were discovered in our laboratory. The cells of some baboon lymphoid cultures, parallel with B-lymphotropic herpesvirus, produced C-type retrovirus antigenically similar to human T-lymphotropic virus (HTLV)-I. The cells of MAL-1, MAL-2 and MAL-3 cultures also produced B-lymphotropic herpesvirus, and small amounts of retrovirus particles were revealed (Fig. 1). Furthermore, it was reported that a number of Old World monkeys, including M. arctoides, can be the carriers of simian T-lymphotropic virus (STLV) related to HTLV-I [3].

Keywords

Lymphoma Leukemia Eosin Fluorescein Isothiocyanate 

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References

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    Lapin BA, Timanovskaya W, Yakovleva LA (1985) Herpesvirus HVMA: a new representative in the group of the EBV-like B-lympho-tropic herpesviruses of primates. In: Neth R et al. (eds) Modern trends in human leukemia VI. Springer, Berlin Heidelberg New York Tokyo, pp 312–313 (Haematology and blood transfusion, vol 29)Google Scholar
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    Miyoshi J, Yoshimoto S, Taguchi H, Kubonishi J, Fujishita M, Ohtsuki Y, Shiraishi Y, Akagi T (1983) Transformation of rabbit lymphocytes with T-cell leukemia virus. Gann 74, 1:1–4PubMedGoogle Scholar
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    Watanabe T, Seiki M, Hirayama Y, Yoshida M (1986) Human T-cell leukemia virus type-1 is a member of the African subtype of simian viruses (STLV). Virology 2:385–388CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. A. Yakovleva
    • 1
  • V. V. Timanovskaya
    • 1
  • A. F. Voevodin
    • 1
  • L. V. Indzhiia
    • 1
  • B. A. Lapin
    • 1
  • M. T. Ivanov
    • 1
  • D. S. Markaryan
    • 1
  1. 1.Institute of Experimental Pathology and TherapyUSSR Academy of Medical SciencesSukhumiUSSR

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