Modelling of Malignant Lymphoma in Rabbits, Using Oncogenic Viruses of Non-Human Primates
The discovery of lymphoid B-lymphotropic herpesvirus-producing cell lines from M. arctoides peripheral lymphocytes (MAL-1) producing their own lymphotropic virus HVMA was reported earlier . Subsequently, two more M. arctoides virus-producing lymphoid cell lines (MAL-2, MAL-3) were discovered in our laboratory. The cells of some baboon lymphoid cultures, parallel with B-lymphotropic herpesvirus, produced C-type retrovirus antigenically similar to human T-lymphotropic virus (HTLV)-I. The cells of MAL-1, MAL-2 and MAL-3 cultures also produced B-lymphotropic herpesvirus, and small amounts of retrovirus particles were revealed (Fig. 1). Furthermore, it was reported that a number of Old World monkeys, including M. arctoides, can be the carriers of simian T-lymphotropic virus (STLV) related to HTLV-I .
KeywordsMalignant Lymphoma Neck Lymph Node Popliteal Lymph Node Mononuclear Peripheral Blood Lymphoid Cell Line
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