Progress in Treatment of Advanced Non-Hodgkin’s Lymphoma in Children — Report on Behalf of the Polish Children’s Leukemia/Lymphoma Study Group

  • J. Bogusławska-Jaworska
  • B. Rodziewicz
  • B. Kazanowska
  • J. Armata
  • R. Cyklis
  • P. Daszkiewicz
  • A. Dłużniewska
  • M. Matysiak
  • M. Ochocka
  • U. Radwańska
  • R. Rokicka-Milewska
  • M. Sroczyńska
  • Z. Wójcik
  • I. Żmudzka
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

It is well known that children with nonHodgkin’s lymphoma (NHL) are highly curable by modern treatment schedules [3]. As has been reported, with the LSA2L2 protocol the Polish Children’s Leukemia/Lymphoma Study Group was able to cure about 90% of NHL children in stages I and II [2]. However, the outcome of disseminated NHL, particularly with initial central nervous system (CNS) or bone marrow (BM) involvement and B-cell histology remained unsatisfactory [2]. Therefore, between 1983 and 1986 two other therapy modalities, COAMP [1] and the Murphy [3] protocols were applied for children with nonlocalized NHL.

Keywords

Lymphoma Cobalt Leukemia Hydrocortisone Methotrexate 

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References

  1. 1.
    Anderson JR, Wilson JS, Jenkin DT, et al. (1983) Childhood non-Hodgkin’s lymphoma. The results of a randomized therapeutic trial comparing a four-drug regimen (COAMP) with a ten-drug regimen (LSA2L2). N Engl J Med 308:559–565PubMedCrossRefGoogle Scholar
  2. 2.
    Boguslawska-Jaworska J, Rodziewicz B, Kazanowska B, Armata J, et al. (1986) Childhood non-Hodgkin’s lymphoma: a review of treatment results in 243 children. In: Büchner T, Schellong G, Hiddemann W, Urbanitz D, Ritter J (eds) Acute leukemias. Springer-Verlag, Berlin Heidelberg New York TokyoGoogle Scholar
  3. 3.
    Murphy SB, Bowmann WP, Hustu HO, Berard CW (1984) Advanced stage III–IV Burkitt’s lymphoma and B-cell ALL in children. Kinetic and pharmacologie rationale for treatment and recent results (1979–1983). In: O’Conor, Lenoir (eds) Burkitt’s lymphomas. IARC-WHO PublicationsGoogle Scholar
  4. 4.
    Wollner N, Exelby P, Lieberman P (1979) Non-Hodgkin’s lymphoma in children. A progress report on the original patients treated with the LSA2L2 protocol. Cancer 44:1990PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. Bogusławska-Jaworska
    • 1
  • B. Rodziewicz
    • 1
  • B. Kazanowska
    • 1
  • J. Armata
    • 1
  • R. Cyklis
    • 1
  • P. Daszkiewicz
    • 1
  • A. Dłużniewska
    • 1
  • M. Matysiak
    • 1
  • M. Ochocka
    • 1
  • U. Radwańska
    • 1
  • R. Rokicka-Milewska
    • 1
  • M. Sroczyńska
    • 1
  • Z. Wójcik
    • 1
  • I. Żmudzka
    • 1
  1. 1.Departments of Pediatric Hematology and Medical Schools of WrocławKraków, Poznań, Warszawa, and ZabrzePoland

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