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Replication and Pathogenesis of the Human T-Cell Leukemia/Lymphotropic Retroviruses

  • Conference paper
Modern Trends in Human Leukemia VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 31))

Abstract

Human retroviruses represent an emerging class of complex pathogens involved in a wide variety of maladies, including leukemias and lymphomas, diseases of the central nervous system, and immune function impairment. These have recently been reviewed by Wong-Staal and Gallo. Four different types of human retroviruses have been isolated to date: the etiological agents of a malignant T cell leukemia/lymphoma, the virus HTLV-I which causes the disease ATLL, two viruses associated with more benign forms of T-cell leukemia (HTLV-II), and the etiological agent of the acquired immune deficiency syndrome and related disorders (HIV). Additionally, retroviruses of genomic organization similar to that of HIV but differing markedly in DNA sequence have recently been isolated among persons in West Africa (Kanki et al. 1985; Clavel et al. 1986).

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Author information

Authors and Affiliations

  1. Laboratory of Biochemical Pharmacology, Dana-Farber Cancer Institute, USA

    W. Haseltine

  2. Department of Pathology, Harvard Medical School, USA

    W. Haseltine

  3. Department of Cancer Biology, Harvard School of Public Health, USA

    W. Haseltine

Authors
  1. W. Haseltine
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  2. J. Sodroski
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  3. C. Rosen
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Institute of Cancer Research, Chester Beatty Laboratories, Leukemia Research Fund Centre, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Hartmut Kabisch

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© 1987 Springer-Verlag Berlin Heidelberg

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Haseltine, W., Sodroski, J., Rosen, C. (1987). Replication and Pathogenesis of the Human T-Cell Leukemia/Lymphotropic Retroviruses. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_85

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  • DOI: https://doi.org/10.1007/978-3-642-72624-8_85

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17754-8

  • Online ISBN: 978-3-642-72624-8

  • eBook Packages: Springer Book Archive

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