v-H-ras Gene Reduces IL-3 Requirement in PB-3c Mastocytes In Vitro Followed by Autokrine Tumor Formation In Vivo

  • Asha P. K. Nair
  • Ch. Moroni
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)


The search for the physiological functions of proto-oncogenes has led to the notion that some code for products involved in control of mitosis as growth factor or growth factor receptor. This association of proto-oncogenes with mitotic control elements is consistent with the hypothesis that changes of various proto-oncogenes correlate with the multistep process of human carcinogesis, and there are numerous reports on specific proto-oncogene alterations in various human malignancies. What is not known, however, is the nature of the involvement of an altered proto-oncogene with the malignant process, i.e., the precise pathogenic role of the protein.


Acute Myeloblastic Leukemia Myelomonocytic Line Cumulative Tumor Incidence Mitogenic Culture 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Asha P. K. Nair
    • 1
  • Ch. Moroni
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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