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v-H-ras Gene Reduces IL-3 Requirement in PB-3c Mastocytes In Vitro Followed by Autokrine Tumor Formation In Vivo

  • Asha P. K. Nair
  • Ch. Moroni
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

The search for the physiological functions of proto-oncogenes has led to the notion that some code for products involved in control of mitosis as growth factor or growth factor receptor. This association of proto-oncogenes with mitotic control elements is consistent with the hypothesis that changes of various proto-oncogenes correlate with the multistep process of human carcinogesis, and there are numerous reports on specific proto-oncogene alterations in various human malignancies. What is not known, however, is the nature of the involvement of an altered proto-oncogene with the malignant process, i.e., the precise pathogenic role of the protein.

Keywords

Acute Myeloblastic Leukemia Myelomonocytic Line Cumulative Tumor Incidence Mitogenic Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Asha P. K. Nair
    • 1
  • Ch. Moroni
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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