Abstract
In the present study we have investigated the association between cell surface molecules and the cytoskeleton in malignant B-chronic lymphocytic leukaemia (B-CLL) cells. The rationale was the observation that close interactions between surface receptors and cytoskeletal proteins are involved in the regulation of several major lymphocyte functions, including activation and recirculation [1]. B-CLL cells were selected for this study for three reasons. First, B-CLL monoclonal B cells have a well-characterized phenotype [2]: they express on the membrane the monoclonal-antibody (MoAb)-defined cluster differentiation (CD) 19, 20, 21, 24 and 5 structures. Second, they have abnormalities that suggest defects of cytoskeleton function, such as the inability to cap surface immunoglobulins (sIg) and other ligand receptors [3].
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References
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© 1987 Springer-Verlag Berlin Heidelberg
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Caligaris-Cappio, F. et al. (1987). Membrane-Microfilament Interactions in the Cells of B-Chronic Lymphocytic Leukemia. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_43
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DOI: https://doi.org/10.1007/978-3-642-72624-8_43
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