Abstract
A wealth of data on B-cell growth and differentiation factors has been published recently, and so many different factors have been shown to act on B cells [1] that it is difficult to determine which, if any, of these factors are physiologically relevant. Initial models assumed that B-cell activation leads to an ordered expression of receptors for specific growth and then differentiation factors, but these now appear to be incorrect. Firstly, most of the factors with functional effects on B cells are not specific for cells of that lineage. IL2, IL1 and IFNγ have all been shown to have effects on B cells [1, 2]. Secondly, BSF-2 (B-cell differentiation factor BCDFγ), which has recently been cloned [3], has been shown to activate mast cells and basophils, and to cause T-cell proliferation [4], while BCGF II acts as a differentiation factor for eosinophils [5].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kishimoto T (1985) Annu Rev Immunol 3:135–159
Melchers F, Anderson J (1984) Cell 37:715–720
Noma Y, Sideras P, Naito T, Bergstedt-Lindquist S, Azuma C, Severinson E, Tanabe T et al. (1986) Nature 319:640–646
Vitetta E (in press) Proceedings of the International Conference on Lymphocyte Activation and Immune Regulation
Sanderson CJ, O’Garra A, Warren DJ, Klaus GGB (1986) Proc Natl Acad Sci USA 83:437–440
Muraguchi A, Kishimoto T, Miki Y, Kuritani T, Kaieda T, Yoshizaki K, Yamamura Y (1981) J Immunol 127:412–416
Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun H, Kishimoto T (1985) Proc Natl Acad Sci USA 82:5490–5494
Golay JT, Rawle FC, Beverley PCL (1985) In: Reinherz EL, Nadler LM (eds) Leucocyte typing II. Springer, Berlin Heidelberg New York Tokyo, pp 463–472
Golay JT, Clark EA, Beverley PCL (1985) J Immunol 135:3795–3801
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rawle, F.C., Armitage, R.J., Beverley, P.C.L. (1987). Human B-Cell Growth and Differentiation Factors, and Their Effects on Leukemic B-Cells. In: Neth, R., Gallo, R.C., Greaves, M.F., Kabisch, H. (eds) Modern Trends in Human Leukemia VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72624-8_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-72624-8_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17754-8
Online ISBN: 978-3-642-72624-8
eBook Packages: Springer Book Archive