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Bone-Marrow Purging with Monoclonal Antibodies and Human Complement in ALL and AML

  • O. Majdic
  • K. Sugita
  • I. Touw
  • U. Köller
  • H. Stockinger
  • R. Delwel
  • B. Löwenberg
  • W. Knapp
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 31)

Abstract

High-dose treatment followed by infusion of histocompatible allogeneic bone marrow has been shown to be curative in many patients with acute leukemia. Inherent in this treatment modality are a number of problems, however. Most prominent among them: graft versus host disease or, when using T cell-depleted marrow, graft failure. In addition, age restriction, conventionally applied to minimize morbidity and mortality, reduces the application of allogeneic bone marrowtransplantation to, on the average, about one third of those with the disease, and of these only about one in three will have a suitable donor.

Keywords

Acute Myeloid Leukemia Acute Leukemia Human Complement Kemic Cell Clonogenic Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • O. Majdic
    • 1
  • K. Sugita
    • 1
  • I. Touw
    • 2
  • U. Köller
    • 1
  • H. Stockinger
    • 1
  • R. Delwel
    • 2
  • B. Löwenberg
    • 2
  • W. Knapp
    • 1
  1. 1.Institute of ImmunologyUniversity of ViennaViennaAustria
  2. 2.Dr. Daniel Den Hoed Cancer CenterRotterdamNetherlands

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