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Konservative Therapie des Prostatakarzinoms pp 21–35Cite as

Tierexperimentelle Modelle zur Therapie des Prostatakarzinoms

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Zusammenfassung

Für Therapiestudien des Prostatakarzinoms stellen wir an Tiermodelle die im folgenden aufgezählten Anforderungen:

  • Spontaner Ursprung

  • Auftreten bei alten Tieren

  • Herkunft von Prostatagewebe

  • Adenokarzinom

  • Langsam wachsend

  • Histologische Ähnlichkeit mit Human-Prostatakarzinom

  • Vergleichbare biochemische Eigenschaften (Phosphatasen↑)

  • Metastasierung in Knochen, Lymphknoten

  • Hormonempfindlichkeit: androgenabhängiges Wachstum.

  • Parallelität im therapeutischen Ansprechen

    1. a)

      bei Hormontherapie (fakultativ auch mit Hormonresistenz)

    2. b)

      Chemotherapie

    3. c)

      Strahlentherapie

  • Heterogene Biologie (nach Differenzierungsgrad, Hormonsensibilität, -Resistenz) entsprechend der menschlichen Karzinomvielfalt.

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Authors
  1. K. M. Schrott
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  2. R. Walther
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Editor information

Editors and Affiliations

  1. im Klinikum Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Reinhard Nagel (Direktor Urologische Klinik und Poliklinik) (Direktor Urologische Klinik und Poliklinik)

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© 1987 Springer-Verlag Berlin Heidelberg

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Schrott, K.M., Walther, R. (1987). Tierexperimentelle Modelle zur Therapie des Prostatakarzinoms. In: Nagel, R. (eds) Konservative Therapie des Prostatakarzinoms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72613-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-72613-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17724-1

  • Online ISBN: 978-3-642-72613-2

  • eBook Packages: Springer Book Archive

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