Synthesis of Triquinane Natural Products
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Hirsutene (1124) is the simplest member of a group of fungal metabolites possessing the linearly fused cis,anti,cis-tricyclo[6.3.0.02,6]undecane carbon skeleton . As a result of the antibiotic and antitumor properties shown by some of these triquinanes, synthetic chemists have strived to devise new annulation procedures for their construction. Several new syntheses of hirsutene itself have recently been reported where a wide range of different strategies to provide access to the tricyclopentanoid ring system are described.
KeywordsBoron Trifluoride Etherate Formal Synthesis Ethyl Diazoacetate Annulation Strategy Hexamethylphosphoric Triamide
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