Abstract
Standard treatment of thalassemia involves frequent blood transfusions to correct anemia and suppress marrow hyperactivity. Chronic iron chelation reduces or prevents hemosiderosis caused by this form of therapy. With this conventional treatment, life expectancy may exceed more than 25 years, and many patients manage to maintain normal activity and, occasionally, to raise families.
Keywords
- Bone Marrow Transplantation
- Marrow Transplantation
- Conditioning Regimen
- Chronic Granulomatous Disease
- Total Body Irradiation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Thomas ED, Buckner CD, Sanders JE et al. (1982) Marrow transplantation for talassemia. Lancet ii: 227–229
Lucarelli G, Izzi T, Polchi P. et al. (1983) Trapianto di midollo osseo nella talassemia. Trans-fus Sangue 1: 62–64
Lucarelli G. Galimberti M, Polchi P. et al (1986) Marrow transplantation in patients with advanced thalassemia. Blood 68: 275
Lucarelli G, Polchi P, Galimberti M, et al. (1987) Bone marrow transplantation in thalassemia. In: Sirchia G, Zanella A (eds) Thalassemia today, the Mediterranean experience. Milan
Clift RA, Hansen JA, Thomas ED et al. (1979) Marrow transplantation from donors other than HLA-identical silbings. Transplantation 28: 235–242
Slavin S and EA Rachmilewitz (1986) Bone marrow transplantation in thalassemia. Bone Marrow Transplant 1: 11–15
Lucarelli G, Polchi P, Galiberti M et al. (1985) Marrow transplantation for thalassemia following Busulphan and cyclophosphamide. Lancet ii: 1355–1357
O’Reilly RJ, Brochstein J, Dinsmore R, Kirkpatrick D (1984) Marrow transplantation for congenital disorders. Semin Hematol 21: 188–221
Lucarelli G, Polchi P, Izzi T, et al. (1984). Allogeneic marrow transplantation for thalassemia. Exp Hematol 12: 676
Lin KH, Lin KS, Feig SA (1986). Marrow transplantation for thalassemia, Bone Marrow Transplantation 1: 115–120
Girolamo G, de Bartolomeo P, Angrilli F et al. (1987). Bone marrow transplantation for refractory anaemia and congenital haemopathies (thalassemias, chronic granulomatous disease, Fanconi’s disease). XIII annual meeting of the EBMT Interlaken, Switzerland, 1–5 March 1987 (Abstr 43).
Anonymous (1981) Community control of hereditary anaemias (Memorandum). Bull WHO, 61: 63
Thomas ED (1985) Marrow transplantation for non malignant disorders. N Engl Med 312: 46–47
Sullivan MK, Joachim-Deeg H, Sanders EJ et al (1984). Late complications after marrow transplantation. Semin Hematol 21: 1
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Rombos, Y. (1989). Bone Marrow Transplantation for Thalassemia Major: The Place of Irradiation. In: Papavasiliou, C., Cambouris, T., Fessas, P. (eds) Radiology of Thalassemia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72587-6_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-72587-6_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72589-0
Online ISBN: 978-3-642-72587-6
eBook Packages: Springer Book Archive