In Vitro Teratogenicity of Parbendazole

  • C. L. Wildgoose
  • C. E. Steele
Conference paper
Part of the Archives of Toxicology, Supplement book series (TOXICOLOGY, volume 11)

Abstract

In order to determine the value of whole embryo culture (WEC) as a screen for teratogens, an attempt was made to reproduce in this system the teratogenic effects seen in routine in vivo reproductive toxicity studies. Parbendazole (SKF 29044) was found to be teratogenic in vivo in the dose range 10–50mg/kg body wt. Litters of pregnant Wistar rats dosed during mid-gestation exhibited malformations which indicated effects in both early (exencephaly, anophthalmia, etc.) and late (retina folding, fused ribs, etc.) organogenesis. The former malformations are such that they could be demonstrated in WEC.

Keywords

Toxicity Retina Toxicology Teratogenicity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. New DAT (1978) Whole-embryo culture and the study of mammalian embryos during organogenesis. Biol Rev 53:81–122PubMedCrossRefGoogle Scholar
  2. Steele CE, New DAT (1974) Serum variants causing the formation of double hearts and other abnormalities in explanted rat embryos. J Embryol Exp Morphol 31:707–719PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • C. L. Wildgoose
    • 1
  • C. E. Steele
    • 1
  1. 1.Department of ToxicologySmith Kline and French Research LimitedWelwynUK

Personalised recommendations