In Vitro Teratogenicity of Parbendazole
In order to determine the value of whole embryo culture (WEC) as a screen for teratogens, an attempt was made to reproduce in this system the teratogenic effects seen in routine in vivo reproductive toxicity studies. Parbendazole (SKF 29044) was found to be teratogenic in vivo in the dose range 10–50mg/kg body wt. Litters of pregnant Wistar rats dosed during mid-gestation exhibited malformations which indicated effects in both early (exencephaly, anophthalmia, etc.) and late (retina folding, fused ribs, etc.) organogenesis. The former malformations are such that they could be demonstrated in WEC.
KeywordsToxicity Retina Toxicology Teratogenicity
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