Abstract
Clinical studies and experimental research have established the teratological relationship between constant ethanol consumption throughout pregnancy, and the occurrence of alcohol embryopathy (AE) in the offspring of alcoholics (as reviewed by Abel, 1982). The implication of social or “binge” drinking is of specific interest because confusion exists concerning advice given to pregnant women about their drinking habits.
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References
Abel EL (1982) Consumption of alcohol during pregnancy: a review of effects on growth and development of offspring. Hum Biol 54:421–453
Abel EL, Dintcheff B (1978) Effects of pre-natal alcohol exposure on growth and development in rats. J Pharmacol Exp Ther 207:916–921
Beck F, Huxham IM, Gulamhusein AP (1984) Growth of rat embryos in the serum of alcohol drinkers. In: Porter et al. (eds) Mechanisms of alcohol damage in utero. Pitman, London, pp 218–233 (CIBA Foundation Symposium 105)
Brown NA, Goulding EH, Fabro S (1979) Ethanol embryotoxicity: direct effects on mammaliam embryos in vitro. Science 206:573–575
Henderson GL, Hoyumpa A, McClain C, Schenker S (1979) The effects of chronic and acute alcohol administration on the fetal development in the rat. Alcoholism Clin Expt Res 3:99–106
Kronick JB (1976) Teratogenic effects of ethyl alcohol administered to pregnant mice. Am J Obstet Gynecol 124:678–680
New DAT (1978) Whole embryo culture and the study of mammalian embryos during organogenesis. Biol Rev 53:81–122
Popov VB, Vaisman BL, Puchkov VF, Ignat’eva TV (1982) Toxic action of ethanol and its biotransformation products on post-implantation rat embryos in culture. Bull Eksp Biol Med 72:1707–1710
Priscott PK (1982) The effects of ethanol on rat embryos developing in vitro. Biochem Pharmacol 31:3641–3643
Sulik KK, Johnston MC, Webb MA (1981) Fetal alcohol syndrome: embryogenesis in a mouse model. Science 214:936–938
Tze WJ, Lee M (1975) Adverse effects of maternal alcohol consumption on pregnancy and foetal growth in rats. Nature 257:479–480
Webster WS, Walsh DA, Lipson AH, McEwen SE (1980) Teratogenesis after acute alcohol exposure in inbred and outbred mice. Neurobehav Toxicol 2:227–234
Wynter JM, Walsh DA, Webster WS, McEwen SE, Lipson AH (1983) Teratogenesis after acute exposure in cultured rat embryos. Teratogenesis Carcinog Mutagen 3:421–428
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© 1987 Springer-Verlag
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Clode, A.M., Pratten, M.K., Beck, F. (1987). The Effect of Ethanol on the Growth of Rat Embryos: The Role of Stage Dependency and Hyperosmolality. In: Chambers, C.M., Chambers, P.L., Davies, D.S. (eds) Mechanisms and Models in Toxicology. Archives of Toxicology, Supplement, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72558-6_25
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DOI: https://doi.org/10.1007/978-3-642-72558-6_25
Publisher Name: Springer, Berlin, Heidelberg
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