Abstract
Most uterine smooth muscle tumors probably arise from the myometrium, which consists of two layers: the inner circular and outer longitudinal muscle layers. Due to their localization in the outer region of the uterine wall, these tumors are usually grossly visible. Leiomyomas and leiomyosarcomas often appear as circumscribed (multi-)nodular or lobulated lesions ranging in size from a few millimeters to bulky masses. Sizes up to 8 cm in diameter have been recorded. Diffuse growth causing enlargement of the entire uterine wall has also been observed in leiomyosarcomas. When large, both of these smooth muscle tumor types may distort the outline of the uterus or its endometrial cavity and may cause displacement of adjacent organs and structures, such as ovaries, colon and urinary bladder.
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© 1987 Springer-Verlag Berlin Heidelberg
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Solleveld, H.A. (1987). Leiomyoma and Leiomyosarcoma, Uterus, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_17
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DOI: https://doi.org/10.1007/978-3-642-72550-0_17
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