Ca2+/Calmodulin-Sensitive Na+/K+-ATPase Activity Expressed in Chimeric Molecules between the Plasma Membrane Ca2+-ATPase and the Na+/K+-ATPase α-Subunit

  • Toshiaki Ishii
  • Kunio Takeyasu


The plasma membrane (PM) Ca2+-ATPase belongs to a family of ion pumps (P-type ATPase) which undergoes a series of conformational changes including a phosphorylated intermediate during the course of ATP-catalysis and cation transport (10). It differs from the sarcoplasmic reticulum (SR) Ca2+-ATPase in its subcellular localization, and consists of a single-type catalytic subunit in contrast to the multi-subunit H+/K+- and Na+/K+-ATPases. An additional distinct feature of the PM Ca2+-ATPase is that its function is regulated by Ca2+/calmodulin.


ATPase Activity Sarcoplasmic Reticulum Homologous Domain Carboxy Terminus Calmodulin Binding 
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Copyright information

© Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt 1994

Authors and Affiliations

  • Toshiaki Ishii
    • 1
  • Kunio Takeyasu
    • 1
  1. 1.Department of Medical Biochemistry and Biotechnology CenterThe Ohio State UniversityColumbusUSA

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