Ca2+/Calmodulin-Sensitive Na+/K+-ATPase Activity Expressed in Chimeric Molecules between the Plasma Membrane Ca2+-ATPase and the Na+/K+-ATPase α-Subunit
The plasma membrane (PM) Ca2+-ATPase belongs to a family of ion pumps (P-type ATPase) which undergoes a series of conformational changes including a phosphorylated intermediate during the course of ATP-catalysis and cation transport (10). It differs from the sarcoplasmic reticulum (SR) Ca2+-ATPase in its subcellular localization, and consists of a single-type catalytic subunit in contrast to the multi-subunit H+/K+- and Na+/K+-ATPases. An additional distinct feature of the PM Ca2+-ATPase is that its function is regulated by Ca2+/calmodulin.
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