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Regulation of the Na+,K+-pump by Insulin

  • Chapter
The Sodium Pump

Abstract

Insulin administration reduces the serum glucose and K+ concentrations (6) by promoting their entry into skeletal muscle (20). The acute function of insulin, thus, is to clear from the blood two of the major nutrients ingested during a meal. Clausen and Kohn (13) and Resh et al. (33) showed that insulin stimulates the activity of the Na+,K+-pump in rat skeletal muscle and adipocytes, respectively, by a direct effect on the pump rather than by an increase in the intracellular Na+ concentration. On the other hand, there are instances in which insulin does stimulate a Na+/H+ exchanger resulting in an increase in intracellular Na+ and increased activity of the (Na+,K+)-pump through an increase in the substrate concentration (15,26,34). The central question here is the mechanism of the direct activation of the (Na+,K+)-pump by insulin.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    Jonathan Lytton, Janet Lin, Luisa DiAntonio, Jeff Brodsky, Julie McGeoch, Diana McGill & Guido Guidotti

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  1. Jonathan Lytton
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  2. Janet Lin
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  3. Luisa DiAntonio
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  4. Jeff Brodsky
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  5. Julie McGeoch
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  6. Diana McGill
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  7. Guido Guidotti
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Biophysik, Kennedyallee 70, 60596, Frankfurt, Germany

    Ernst Bamberg

  2. Institut für Biochemie, Universität Gießen, Frankfurter Str. 100, 35392, Gießen, Germany

    Wilhelm Schoner

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© 1994 Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Lytton, J. et al. (1994). Regulation of the Na+,K+-pump by Insulin. In: Bamberg, E., Schoner, W. (eds) The Sodium Pump. Steinkopff. https://doi.org/10.1007/978-3-642-72511-1_121

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  • DOI: https://doi.org/10.1007/978-3-642-72511-1_121

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72513-5

  • Online ISBN: 978-3-642-72511-1

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