Skip to main content
SpringerLink
Log in

Heterogeneity of distribution and of regulation by corticosteroids of transport ATPases along the rat collecting tubule

  • Chapter
The Sodium Pump

Abstract

In rodents, the pH of the tubular fluid decreases as it flows along the inner medullary collecting duct (IMCD) towards the tip of the papilla (17,18, 30), indicating that this nephron segment is an important site of urinary acidification. This acidification primarily results from active proton secretion rather than bicarbonate reabsorption since it is accompanied with a luminal acidic disequilibrium pH (8, 16). However, there is little information concerning the molecular mechanism of apical proton secretion in this nephron segment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ait-Mohamed AK, Marsy S, Barlet C, Khadouri C, Doucet A (1986) Characterization of N-ethylmaleimide-sensitive proton pump in the rat kidney. Localization along the nephron. J Biol. Chem 261: 12526–12533

    PubMed  CAS  Google Scholar 

  2. Alexander EA, Schwartz JH (1991) Regulation of acidification in the rat inner medullary collecting duct. Am J Kidney Dis 18: 612–618

    PubMed  CAS  Google Scholar 

  3. Brown D, Hirsch S, Gluck S (1988) Localization of a proton-pumping ATPase in rat kidney. J Clin Invest 82: 2114–2126

    Article  PubMed  CAS  Google Scholar 

  4. Cheval L, Barlet-Bas C, Khadouri C, Féraille E, Marsy S, Doucet A (1991) K-ATPase-mediated Rb transport in the rat collecting tubule: modulation during K-depletion. Am J Physiol 260: F800–F805

    PubMed  CAS  Google Scholar 

  5. Clapp WL, Madsen KM, Verlander JW, Tisher CC (1987) Intercalated cells of the rat inner medullary collecting duct. Kidney Int 31: 1080–1087

    Article  PubMed  CAS  Google Scholar 

  6. Doucet A, Katz AI, Morel F (1979) Determination of Na-K-ATPase activity in single segments of the mammalian nephron. Am J Physiol 237: F105–F113

    PubMed  CAS  Google Scholar 

  7. Doucet A, Marsy S (1987) Characterization of K-ATPase activity in distal nephron: stimulation by potassium depletion. Am J Physiol 253: F418–F423

    PubMed  CAS  Google Scholar 

  8. Dubose TD Jr (1982) Hydrogen ion secretion by the collecting duct as a determinant of the urine to blood PCO gradient in alkaline urine. J Clin Invest 69: 145–156

    Article  PubMed  Google Scholar 

  9. El Mernissi G, Doucet A (1983) Short-term effect of aldosterone on renal sodium transport and tubular Na-K-ATPase in the rat. Pflügers Arch 399: 139–146

    Article  PubMed  CAS  Google Scholar 

  10. Garg LC (1991) Effects of aldosterone on H-K-ATPase activity in rabbit nephron segments. In: Aldosterone: Fundamental Aspects, edited by J.P. Bonvalet, N. Farman, M. Lombés and M.E. Rafestin-Oblin. Paris, John Libbey Eurotext,p.328 (Abst.)

    Google Scholar 

  11. Garg LC, Narang N (1985) Stimulation of an N-ethylmaleimide-sensitive ATPase in the collecting duct segments of the rat nephron by metabolic acidosis. Can J Physiol Pharmacol 63: 1291–1296

    Article  PubMed  CAS  Google Scholar 

  12. Garg LC, Narang N (1988) Ouabain-insensitive K-adenosine triphosphatase in distal nephron segments of rabbit. J Clin Invest 81: 1204–1208

    Article  PubMed  CAS  Google Scholar 

  13. Garg LC, Narang N (1988) Effects of aldosterone on NEM-sensitive ATPase in rabbit nephron segments. Kidney Int 34: 13–17

    Article  PubMed  CAS  Google Scholar 

  14. Gifford JD, Rome L, Galla JH (1992) H+-K+-ATPase activity in rat collecting duct segments. Am J Physiol 262: F692–F695

    PubMed  CAS  Google Scholar 

  15. Graber ML, Bengele HH, Mroz E, Lechene C, Alexander EA (1981) Acute metabolic acidosis augments collecting duct acidification rate in the rat. Am J Physiol 241: F669–F676

    PubMed  CAS  Google Scholar 

  16. Graber ML, Bengele HH, Schwartz JH, Alexander EA (1981) pH and pCO2 profiles of the rat inner medullary collecting duct. Am J Physiol 241: F659–F668

    PubMed  CAS  Google Scholar 

  17. Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S (1992) Immunologic evidence that vacuolar H-ATPases with heterogeneous forms of Mr = 31.000 subunit have different membrane distributions in mammalian kidney. J Biol. Chem 267: 9948–9957

    PubMed  CAS  Google Scholar 

  18. Hierholzer K (1961) Secretion of potassium and acidification in collecting ducts of mammalian kidney. Am J Physiol 201: 318–324

    PubMed  CAS  Google Scholar 

  19. Khadouri C, Cheval L, Marsy S, Barlet-Bas C, Doucet A (1991) Characterization and control of proton-ATPases along the nephron. Kidney Int 40: S71–S78

    Google Scholar 

  20. Khadouri C, Marsy S, Barlet-Bas C, Doucet A (1987) Effect of adrenalectomy on NEM-sensitive ATPase along the rat nephron and on urinary acidification. Am J Physiol 253: F495–F499

    PubMed  CAS  Google Scholar 

  21. Madsen KM, Tisher CC (1986) Structural-functional relationship along the distal nephron. Am J Physiol 250: F1–F15

    CAS  Google Scholar 

  22. Madsen KM, Clapp WL, Verlander JW (1988) Structure and function of the inner medullary collecting duct. Kidney Int. 34: 441–454

    Article  PubMed  CAS  Google Scholar 

  23. Matsushima Y, Yoshitomi K, Koseki C, Kawamura M, Akabane S, Imanishi M, Imai M (1990) Mechanisms of intracellular pH regulation in the hamster inner medullary collecting duct perfused in vitro. Pflügers Arch 416: 715–721

    Article  PubMed  CAS  Google Scholar 

  24. Nord EP, Hart D (1991) Polarized distribution of Na+ /H+ antiport and Na+/HCO3 cotransport in primary cultures of rat inner medullary collecting duct cells. J Biol. Chem 266: 2374–2382

    PubMed  Google Scholar 

  25. Planelles G, Anagnostopoulos T, Cheval L, Doucet A (1991) Biochemical and functional characterization of H-K-ATPase in the distal amphibian nephron. Am J Physiol 260: F806–F812

    PubMed  CAS  Google Scholar 

  26. Sabatini S, Laski ME, Kurtzman NA (1990) NEM-sensitive ATPase activity in rat nephron: effect of metabolic acidosis and alkalosis. Am J Physiol 258: F297–F304

    PubMed  CAS  Google Scholar 

  27. Sands J M, Knepper M A (1987) Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium. J Clin Invest 79: 138–147

    Article  PubMed  CAS  Google Scholar 

  28. Sands JM, Nonoguchi H, Knepper MA (1987) Vasopressin effects on urea and H.O transport in inner medullary collecting duct subsegments. Am J Physiol 253: F823–F832

    PubMed  CAS  Google Scholar 

  29. Terada Y, Knepper MA (1989) Na-K-ATPase activities in renal tubule segments of rat inner medulla. Am J Physiol 256: F218–F223

    PubMed  CAS  Google Scholar 

  30. Ullrich KJ, Eigler FW (1958) Sekretion von Wasserstoffionen in den Sammelrohren der Sungetierniniere. Pflügers Arch 267: 491–496

    Article  PubMed  CAS  Google Scholar 

  31. Wang ZQ, Gluck S (1990) Isolation and properties of bovine kidney brush border vacuolar H-pump: A proton pump with enzymatic and structural differences from kidney microsomal H-ATPase. J Biol. Chem 265: 21957–21965

    PubMed  CAS  Google Scholar 

  32. Wingo CS (1989) Active proton secretion and potassium absorption in the rabbit outer medullary collecting duct. Functional evidence for proton-potassium-activated adenosine triphosphatase. J Clin Invest 84: 361–365

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire, Collège de Fiance, 11 Place M. Berthelot, 75231, Paris Cedex 05, France

    C. Khadouri, C. Barlet-Bas, S. Marsy, L. Cheval & A. Doucet

Authors
  1. C. Khadouri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Barlet-Bas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Marsy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Cheval
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Doucet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Biophysik, Kennedyallee 70, 60596, Frankfurt, Germany

    Ernst Bamberg

  2. Institut für Biochemie, Universität Gießen, Frankfurter Str. 100, 35392, Gießen, Germany

    Wilhelm Schoner

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

About this chapter

Cite this chapter

Khadouri, C., Barlet-Bas, C., Marsy, S., Cheval, L., Doucet, A. (1994). Heterogeneity of distribution and of regulation by corticosteroids of transport ATPases along the rat collecting tubule. In: Bamberg, E., Schoner, W. (eds) The Sodium Pump. Steinkopff. https://doi.org/10.1007/978-3-642-72511-1_119

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72511-1_119

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72513-5

  • Online ISBN: 978-3-642-72511-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation