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Characteristics of transport processes involved in ischemia and reperfusion

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Myocardial Ischemia and Arrhythmia

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Summary

Intracellular homeostasis and the transmembrane transport processes involved depend crucially on driving forces as well as on transport capacities. Normoxic or hypoxie steady-state conditions are characterized by balance of the mechanisms involved, including the level of free energy provided by ATP hydrolysis which is required for active transport. At the transition from ischemia to reperfusion the low transport capacity of the lactate/H+-symporter and the high capacity of the Na+ /H+ -antiporter prevent H+ removal by the former and lead to Na+ accumulation and lowering of the driving force for Na+ by the latter. The intracellular calcium accumulation resulting from the lowered driving force of Na+ in the Na+ /Ca ++-antiporter seems to be one of the most important factors of reperfusion injury.

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Authors and Affiliations

  1. Institut für Physiologie, Med. Fakultät RWTH Aachen, Pauwelsstr. 30, D-52057, Aachen, Germany

    Prof. Dr. H. Kammermeier

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  1. Prof. Dr. H. Kammermeier
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Editors and Affiliations

  1. Abt. Innere Medizin III, Medizinische Universitätsklinik, Hugstetter Straße 55, 79106, Freiburg, Germany

    M. Zehender  & H. Just  & 

  2. Innere Medizin, Universitätskrankenhaus Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    T. Meinertz

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© 1994 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Kammermeier, H. (1994). Characteristics of transport processes involved in ischemia and reperfusion. In: Zehender, M., Meinertz, T., Just, H. (eds) Myocardial Ischemia and Arrhythmia. Steinkopff. https://doi.org/10.1007/978-3-642-72505-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-72505-0_5

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72507-4

  • Online ISBN: 978-3-642-72505-0

  • eBook Packages: Springer Book Archive

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