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Myocardial Ischemia and Arrhythmia pp 145–155Cite as

Factors determining the arrhythmogenic potency of myocardial ischemia and time course of ischemia related arrhythmias

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Summary

Ventricular arrhythmias which occur in the pre-hospital stage of a myocardial infarction constitute a major cause of death. Acute myocardial ischemia causes multiple electrophysiologic abnormalities which arise from a variety of factors such as extracellular K+ accumulation, increased membrane conductance to K+, intracellular acidosis, increased intracellular [Ca2+], catecholamine release, and accumulation of lysophospholipids and free fatty acid esters. There may be profound changes in all these factors during the first 10–15 min of myocardial ischemia and the arrhythmogenic potency of myocardial ischemia is related to the interplay of these multiple factors.

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Author information

Authors and Affiliations

  1. Departments of Anesthesiology and Medicine, MacDonald Research Laboratories, CA, 90024, USA

    J. N. Weiss

  2. Departments of Anesthesiology and Medicine MacDonald Research Laboratories, UCLA School of Medicine Los Angeles, Rm. 3645 675 Circle Drive , Los Angeles, CA, 90024, USA

    Dr. N. Deutsch

Authors
  1. Dr. N. Deutsch
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  2. J. N. Weiss
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Editors and Affiliations

  1. Abt. Innere Medizin III, Medizinische Universitätsklinik, Hugstetter Straße 55, 79106, Freiburg, Germany

    M. Zehender  & H. Just  & 

  2. Innere Medizin, Universitätskrankenhaus Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    T. Meinertz

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© 1994 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Deutsch, N., Weiss, J.N. (1994). Factors determining the arrhythmogenic potency of myocardial ischemia and time course of ischemia related arrhythmias. In: Zehender, M., Meinertz, T., Just, H. (eds) Myocardial Ischemia and Arrhythmia. Steinkopff. https://doi.org/10.1007/978-3-642-72505-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-72505-0_10

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-72507-4

  • Online ISBN: 978-3-642-72505-0

  • eBook Packages: Springer Book Archive

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