Cellular and molecular alterations in the failing human heart
Regarding research on heart failure, experimental studies on isolated myocardium have been restricted to animal models for many years. The transfer of results obtained from animal studies to heart failure in the human being is questionable, because of the differences between species on the one hand, and experimental methods of heart failure induction on the other. With increasing frequency of cardiac transplantation during the last few years, studies were performed on isolated myocardium from failing and non-failing human hearts, using different methods to preserve and prepare human myocardium for in vitro studies.
KeywordsSarcoplasmic Reticulum Myosin Heavy Chain Human Heart Calcium Handling Human Myocardium
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