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Cellular and molecular alterations in the failing human heart

  • Ch. Holubarsch
  • G. Hasenfuss
Conference paper

Abstract

Regarding research on heart failure, experimental studies on isolated myocardium have been restricted to animal models for many years. The transfer of results obtained from animal studies to heart failure in the human being is questionable, because of the differences between species on the one hand, and experimental methods of heart failure induction on the other. With increasing frequency of cardiac transplantation during the last few years, studies were performed on isolated myocardium from failing and non-failing human hearts, using different methods to preserve and prepare human myocardium for in vitro studies.

Keywords

Sarcoplasmic Reticulum Myosin Heavy Chain Human Heart Calcium Handling Human Myocardium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Limas CJ, Olivari MT, Goldenberg IF, Levine TB, Benditi DG, Simon A (1987) Calcium uptake by sarcoplasmic reticulum in human dilated cardiomyopathy. Cardio vase Res 21: 601–605CrossRefGoogle Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co.KG, Darmstadt 1992

Authors and Affiliations

  • Ch. Holubarsch
    • 1
    • 2
    • 3
  • G. Hasenfuss
    • 1
    • 2
    • 3
  1. 1.Dept. of CardiologyMedizinische UniversitätsklinikFreiburgGermany
  2. 2.Dept. of CardiologyMedizinische Universitätsklinik, University of FreiburgFreiburgGermany
  3. 3.Dept. of CardiologyMedizinische Universitätsklinik University of FreiburgFreiburgGermany

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