Pathophysiology of cardiac hypertrophy and failure of human working myocardium: abnormalities in calcium handling

  • A. J. Meuse
  • C. L. Perreault
  • James P. Morgan


Abnormal intracellular calcium ([Ca2+]i) handling appears to be a major cause of both systolic and diastolic dysfunction in animals and human beings with hypertrophy and/or heart failure. We utilized the bioluminescent calcium indicator aequorin to examine the cyclical variations in intracellular calcium levels during isometric contractions. Studies of ventricular muscle from patients with end-stage heart failure exhibited three physiologic findings not seen in preparations taken from normal hearts including: 1) abnormalities in calcium handling; 2) deficient production of cyclic AMP; and 3) a reversed force-frequency relationship. These observations have important implications with regard to the pathogenesis and therapeutics of heart failure in man.

Key words

Calcium heart failure diastolic dysfunction systolic dysfunction 


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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co.KG, Darmstadt 1992

Authors and Affiliations

  • A. J. Meuse
    • 1
  • C. L. Perreault
    • 1
    • 2
  • James P. Morgan
    • 1
    • 2
    • 3
  1. 1.Charles A. Dana Research Institute of the Harvard-Thorndike LaboratoryBeth Israel Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Medicine (Cardiovascular Division)Beth Israel Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Cardiovascular DivisionBeth Israel HospitalBostonUSA

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