Summary
To elucidate the diagnostic value of Atrial Natriuretic Peptide (ANP), ANP plasma concentrations were determined by radioimmunoassay in 15 patients with coronary or valvular heart diseases who were to undergo right-heart catheterization during treadmill exercise. Continuous right atrial — (pRA), pulmonary artery — (pPA), pulmonary wedge pressures (pPC), and heart rate (HR) were correlated to ANP levels in pulmonary artery (PA), brachial artery (A), and peripheral vein (V); the best correlation was found between ANP (PA) and pPC with r=0.59 in linear regression analysis whereas no correlation was seen between HR and ANP values in PA, A and V during exercise.
With increased strain ANP concentration rose significantly in V, A and in PA (35 fmol/ml to 89 fmol/ml). ANP plasma levels were identical in A and PA, but were systematically lower in V compared to A and PA. During the first three minutes after starting treadmill exercise ANP increase in V was significantly (p<0.01) delayed, whereas ANP concentrations in A and PA rose immediately.
The data suggest that elevation of ANP during graded exertion is caused by an increase in atrial pressure and not by a rise in HR. Since there is only a quantitatively weak correlation between ANP plasma concentrations and pressures in the pulmonary circulation the predictive value of ANP levels in individual cases is limited.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, J.V., Donckier, J., McKenna, W.J., Bloom, S.R. (1986) The plasma release of atrial natriuretic peptide in man. Clin Science 71: 151–155
Raine, A.E.G., Erne, P., Bürgisser, E., Müller, F.B., Bolli, F., Burkart, F., Bühler, F.R. (1986) Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315: 533–537
Ledsome, J.R., Wilson, N., Courneya, C.A., Rankin, A.J. (1985) Release of atrial natriuretic peptide by atrial distention. Can J Physiol Pharmacol 63: 739–742
Petzl, D.H., Hartter, E., Osterode, W., Boehm, H., Woloszczuk, W. (1987) Atrial natriuretic peptide release due to physical exercise in healthy persons and in cardiac patients. Klin Wochenschr 65: (4) 194–196
Richards, A.M., Tonolo, G., Cleland, J.G., McIntyre, G.D., Leckie, B.J., Dargie, H.J., Ball, S.G., Robertson, J.I. (1987) Plasma atrial natriuretic peptide concentrations during exercise in sodium replete and deplete normal man. Clin Sci 72 (2): 159–164
Punzengruber, C., Hartter, E., Weissel, M., Burghuber, O.C., Ludvik, B., Woloszczuk, W. (1987) Periphere and rechtsatriale Plasmaspiegel des atrialen natriuretischen Peptids und ihre Beziehung zum atrialen Mitteldruck. Z Kardiol 76: 72–75
Eisenhauer, T., Talartschik, J., Scheler, F (1986) Detection of fluid overload by plasma concentration of human atrial natriuretic peptide (h-ANP) in patients with renal failure. Klin Wochenschr 64 (suppl VI): 68–72
Sato, F., Kamoi, K., Wakiya, Y., Ozawa, T., Arai, O., Ishibashi, M., Yamaji (1986) Relationship between plasma atrial natriuretic peptide levels and atrial pressure in man. J Clin Endocrinol Metab 63 (4): 823–827
Wambach, G., Hannekum, A., Schmidt, S., Kaufmann, W., Dalichau, H. (1987) Erhöhte Konzentrationen des atrialen natriuretischen Peptids im Plasma und im Herzvorhof bei Patienten mit Aorten- und Mitral-vitien im Vergleich zu Patienten mit koronarer Herzkrankheit. Z Kardiol 76 (2): 76–80
Talartschik, J., Eisenhauer, T., De Vivie, R., Talartschik, B., Scheler, F. (1987) Release of atrial natriuretic peptide during cardiac arrest and after resuscitation in 19 patients undergoing cardiac surgery with cardiopulmonary bypass. In: Brenner, B.M., Laragh, J.H. (eds) Advances in Atrial Peptide Research, Vol.2. Raven Press, New York, pp 488–492
Lang, R.E., Dietz, R., Merkel, A., Unger, T., Ruskoaho, H., Ganten, D. (1986) Plasma atrial natriuretic peptide values in cardiac disease. J Hypertension 4 (2): 119–123
Akabane, S., Kojima, S., Igarashi, Y., Kawamura, M., Matsushima, Y., Ito, K. (1987) Release of atrial natriuretic polypeptide by graded right atrial distention in anaesthetized dogs. Life Sci 40 (2): 119–125
Crozier, J.G., Nicholls, M.G., Ikram, H., Espiner, E.A., Yandle, T.G., Jans, S. (1986) Atrial natriuretic peptide in humans. Production and clearance by various tissues. Hypertension 8 (suppl II): II-11–II-15
Yandle, T.G., Richards, A.M., Nicholls, M.G., Cuneo, R., Espiner, E.A., Livesey, J.H. (1986) Metabolic clearance rate and plasma half-life of alpha-human atrial natriuretic peptide in man. Life Sci 38: 1827–1833
Bates, E.R., Shenker, Y., Grekin, R.J. (1986) The relationship between plasma levels of immunoreactive atrial natriuretic hormone and hemodynamic function in man. Circulation 73 (6): 1155–1161
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1989 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt
About this paper
Cite this paper
Talartschik, J., Scholz, K.H., Eisenhauer, T., Neuhaus, K.L. (1989). Plasma concentrations of atrial natriuretic peptide (α- h-ANP 1–28) during exercise and relationship to hemodynamic parameters in man. In: Forssmann, WG., Scheuermann, D.W., Alt, J. (eds) Functional Morphology of the Endocrine Heart. Steinkopff. https://doi.org/10.1007/978-3-642-72432-9_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-72432-9_19
Publisher Name: Steinkopff
Print ISBN: 978-3-642-72434-3
Online ISBN: 978-3-642-72432-9
eBook Packages: Springer Book Archive