Abstract
Hyperuricemia has been reported in a substantial proportion of patients with hyperparathyroidism (hyperPT) and with hypoparathyroidism (hypoPT) (1). The mechanism of the hyperuricemia in both parathyroid disorders has not conclusively been clarified. In both parathyroid abnormalities the hyperuricemia was postulated to reflect decreased renal urate clearance, attributed in hyperPT to a transitory renal tubular damage (2) and in hypoPT to a tubular abnormality associated with the decreased renal phosphate clearance (3). The present study was undertaken in order to assess the prevalence of hyperuricemia in the parathyroid disorders and in order to improve our knowledge of the renal urate handling in the various states of parathyroid pathology.
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References
Stanbury, J. B., Wyngaarden, J. B., Fredrickson, D. S. (eds.): The metabolic basis of inherited disease, 4th edn., pp. 985–986. McGraw-Hill, New York (1978).
Scott, J. T., Dixon, A. St. J., Bywaters, E. G. L.: Association of Hyperuricemia and Gout with Hyperparathyroidism. Brit. Med. J. 1: (No. 5390) 1070 (1964).
Dubin, A., Kushner, D. S., Bronsky, D., Pascale, L. R.: Hyperuricemia in Hypoparathyroidism. Metabolism 5: 703(1956).
Mintz, D. H., Canyry, J. J., Carreon, G., Kyle, L. H.: Hyperuricemia in Hyperparathyroidism. New Eng. J. Med. 265: 112(1961).
Castrillo, J. M., Diaz-Curiel, M., Rapado, A. J.: High Serum Uric Acid in Primary Hyperparathyroidism: Incidence and Follow-Up after Surgery. Clin. Chem. Clin. Biochem. 20: 356 (1982).
Shelp, W. D., Steele, T. H., Reiselbach, R. E.: Comparison of Urinary Phosphate, Urate and Magnesium Excretion Following Parathyroid Hormone Administration to Normal Men.
Epstein, H. J.: Calcium and Kidney. Chronic Dis. 11: 255 (1960).
Engfeldt, B.: Ritodin J., Gardell S., Hellstrom J., Ivemark B., and Strand H.: Effect of Experimentally Induced Hyperparathyroidism on Renal Function and Structure. Acta Endocrinol. 29:15 (1958).
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© 1984 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG., Darmstadt
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Arie, R., Samuel, R., Halabe, A., Liberman, U.A., Sperling, O. (1984). Serum Urate and Renal Urate Clearance in Parathyroid Disorders. In: Vahlensieck, W., Gasser, G. (eds) Pathogenese und Klinik der Harnsteine X. Fortschritte der Urologie und Nephrologie, vol 22. Steinkopff. https://doi.org/10.1007/978-3-642-72370-4_38
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DOI: https://doi.org/10.1007/978-3-642-72370-4_38
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