Abstract
The androgen receptor (AR1) is a member of the steroid receptor family of nuclear transcription factors, whose action requires the binding of ligand. Upon binding of androgens the AR undergoes a conformational change that converts it to the active DNA-binding state. Interaction of the active ligand- bound AR with the hormone response element enhancer sequence in the promoter region of a target gene, in the presence of appropriate co-factors, alters the rate of transcription of the target gene. These events underlie the mechanism of androgen action. AR is found ubiquitously throughout mammalian tissues, implying that androgens have diverse roles not only in development and maintenance of male sexual function, but also in many other sexually dimorphic processes, from modulation of immune function, to development of neural tissues.
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Quigley, C.A. (1998). The androgen receptor: Physiology and pathophysiology. In: Nieschlag, E., Behre, H.M. (eds) Testosterone. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72185-4_2
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