Zusammenfassung
Die Sterblichkeit durch die Dysfunktion multipler Organe bzw. die Sepsis, die zur Organdysfunktion führt, ist trotz aller Fortschritte der intensivmedizinischen Therapie mit einer Letalität von 50 bis 70% unverändert hoch [1]. Das Multiorgandysfunktionssyndrom ist der klinische Endpunkt des fortschreitenden septischen Prozesses, der vorwiegend Patienten mit Peritonitis, nekrotisierender Pankreatitis, Schock, postoperativer Sepsis oder nosokomialen Pneumonien betrifft [2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ (1995) Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23:1638–1652
Goris RJA, to Broekhorst TPA, Nuytinck JKS, Gimbere JSF (1985) Multiple-organ failure-generalized autodestructive inflammation? Arch Surg 120:1109–1115
Christman JW, Holden EP, Blackwell TS (1995) Strategies for blocking the systemic effects of cytokines in the sepsis syndrome. Crit Care Med 23:955–963
Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA (1991) Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 110:192–198
Montravers P, Fagon JY, Gilber C, Blanchet F, Novara A, Chastre J (1993) Pilot study of cardiopulmonary risk from pentoxifylline in adult respiratory distress syndrome. Chest 103:1017–1022
Zeni F, Pain P, Vindimian M, Gay JP, Bertrand M, Page Y, Vermesch R, Bertrand JC (1996) Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: results from a double-blind, randomized, placebo-controlled study. Crit Care Med 24:207–214
Bone RC, Sprung CL, Sibbald WJ (1992) Definitions for sepsis and organ failure. Crit Care Med 20:724–726
Fisher CJ, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RMH, Benjamin E (1996) Treatment of septic shock with the tumor necrosis receptor:Fc fusion protein. N Engl J Med 334:1697–1702
Ridings PC, Windsor ACJ, Sugerman HJ, Kennedy E, Sholley MM, Blocher CR, Fisher BJ, Fowler AA (1994) Beneficial cardiopulmonary effects of pentoxifylline in experimental sepsis are lost once septic shock is established. Arch Surg 129:1144–1152
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schröder, J., Staubache, K.H., Stüber, F., Zabel, P. (1998). Pentoxifyllin als adjuvante Therapie der Multiorgandysfunktion. In: Herfarth, C., Rothmund, M., Hartel, W. (eds) Chirurgisches Forum ’98. Langenbecks Archiv für Chirurgie, vol I/98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72182-3_98
Download citation
DOI: https://doi.org/10.1007/978-3-642-72182-3_98
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-64277-0
Online ISBN: 978-3-642-72182-3
eBook Packages: Springer Book Archive