Skip to main content
SpringerLink
Log in

Introduction

  • Chapter
Inhibitors of Cell Growth

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 20))

  • 223 Accesses

Abstract

The understanding of the mechanisms of the inhibition of cell proliferation concerns developmental processes such as the size of organs and organisms, cell differentiation, cell renewal during the animal life span, aging, and abnormal cell growth. This explains why growth inhibitors can be so versatile (for instance, interferon), their mechanism of action being as complex as the processes they regulate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abrieu A, Dorée M, Picard A (1997) Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested ocytes. Mol Biol Cell 8: 249–261

    PubMed  CAS  Google Scholar 

  • Agarwal ML, Agarwal A, Taylor WR, Stark GR (1995) p53 controls both the G2/M and the G1 cell-cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 92: 8493–8497

    Article  PubMed  CAS  Google Scholar 

  • Alessandrini A, Chiaur DS, Pagano M (1997) Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia 11: 342–345

    Article  PubMed  CAS  Google Scholar 

  • Balza E, Borsi L, Allemani G, Zardi L (1988) Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts. FEBS Lett 228: 42–44

    Article  PubMed  CAS  Google Scholar 

  • Berezney R, Coffey DS (1975) Nuclear protein matrix: association with newly synthesized DNA. Science 189: 291–293

    Article  PubMed  CAS  Google Scholar 

  • Bouvier D, Hubert J, Seve AP, Bouteille M (1985) Characterization of lamina-bound chromatin in the nuclear shell isolated from HeLa cells. Exp Cell Res 156: 500–512

    Article  PubMed  CAS  Google Scholar 

  • Brancolini C, Bottega S, Schneider C (1992) Gast, a growth arrest-specific protein, is a component of the microfilament nework system. J Cell Biol 117: 1251–1261

    Article  PubMed  CAS  Google Scholar 

  • Bryckaert MC, Lindroth M, Lönn A, Tobelem G, Wasteson A (1988) Transforming growth factor (TGF beta) decreases the proliferation of human bone marrow fibroblasts by inhibting the platelet-derived growth factor ( PDGF) binding. Exp Cell Res 179: 311–321

    Google Scholar 

  • Campbell GS, Yu Cl, Jove R, Carter-Su C (1997) Constitutive activation of JAKI is src-transformed cells. J Biol Chem 272: 2591–2594

    Article  PubMed  CAS  Google Scholar 

  • Charp PA, Kinders RJ, Johnson JC (1983) G2 cell-cycle arrest induced by glycopeptides isolated from the bovine cerebral cortex. J Cell Biol 97: 311–316

    Article  PubMed  CAS  Google Scholar 

  • Crossin KL, Carney DH (1981) Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis. Cell 23: 61–71

    Article  PubMed  CAS  Google Scholar 

  • Crothers DM, Haran TE, Nadeau JG (1990) Intrinsically bent DNA. J Biol Chem 265: 7093–7095

    PubMed  CAS  Google Scholar 

  • Das HR, Lavin M, Sicuso A, Young DV (1983) The uncoupling of macromolecular synthesis from cell division in SV3T3 cells by glucocorticoids: the imposition of a G2 block. J Cell Phys 117: 241–248

    Article  CAS  Google Scholar 

  • Diatloff C, Bengtson A, Billardon C, Macieira-Coelho A (1978) Lack of DNA synthesis inhibitory activity in an immunosuppressor obtained from spleen. Cell Tissue Kinet 11: 317–322

    PubMed  CAS  Google Scholar 

  • Edgar BA, O’Farrell (1990) The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell 62: 469–480

    CAS  Google Scholar 

  • Epifanova OI, Brooks RF (1994) Negative control of cell proliferation in eukaryotes. Cell Prolif 27: 373–394

    Article  CAS  Google Scholar 

  • Gelfant S (1977) A new concept of tissue and tumor cell proliferation. Cancer Res 37:3845–3862 Gerace L (1985) Structural proteins in the eukaryotic nucleus. Nature 318: 508–509

    Google Scholar 

  • Haddox MK, Russell DH (1979) Cell cycle-specific locus of vitamin A inhibition of growth. Cancer Res 39: 2476–2480

    PubMed  CAS  Google Scholar 

  • Harold F (1986) A study of bioenergetics. WH Freeman, New York, 500 pp

    Google Scholar 

  • Harper JW (1997) Cyclin-dependent kinase inhibitors. Cancer Sury 29: 91–108

    CAS  Google Scholar 

  • Hay M, Deboni U (1991) Chromatin motion in neuronal interphase nuclei–changes induced by disruption of intermediate filaments. Cell Motil Cytoskeleton 18: 63–70

    Article  PubMed  CAS  Google Scholar 

  • Hobeika AC, Subramaniam, Johnson HM (1997) IFN alpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. Oncogene 14: 1165–1170

    Article  PubMed  CAS  Google Scholar 

  • Jackman MR, Pines JN (1997) Cyclins and the G(2)/M transition. Cancer Sury 29: 47–74

    CAS  Google Scholar 

  • Jackson DA, McCready SJ, Cook PR (1984) Replication and transcription depend on attachment of DNA to the nuclear cage. J Cell Sci Suppl 1: 59–79

    PubMed  CAS  Google Scholar 

  • Karantza V, Maroo A, Fay D, Sedivy JM (1993) Overproduction of Rb protein after G1/S boundary causes ( G2 arrest. Mol Cell Biol 13: 6640–6652

    Google Scholar 

  • King RW, Jackson PK, Kirchner MW (1994) Mitosis in transition. Cell 79: 563–571

    Article  PubMed  CAS  Google Scholar 

  • Krek W, Nigg EA (1991) Differential phosphorylation of vertebrate p34 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J 10: 305–316

    PubMed  CAS  Google Scholar 

  • Kuniyasu H, Yasui W, Ketahara K, Naka K, Yokosaki H, Akama Y, Hamamoto T, Tahara H, Tahara E (1997) Growth inhibitory effect of interferon beta is associated with the induction of cyclin-dependent kinase inhibitor p27 ( Kipl) in a human gastric carcinoma cell line. Cell Growth Differ 8: 47–52

    Google Scholar 

  • L’Allemain G, Franchi A, Cragoe E Jr, Pouysségur J (1984) Blockade of the Na ’/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. J Biol Chem 259: 4313–4319

    PubMed  Google Scholar 

  • Lamb NJC, Fernandez A, Watrin A, Labbé JC, Cavadore JC (1990) Microinjection of p34 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Cell 60: 151–165

    Article  PubMed  CAS  Google Scholar 

  • Lorber M, Milobsky SA (1968) Stretching of the skin in vivo. A method of influencing cell division and migration in the rat epidermis. J Invest Dermatol 51: 395–402

    Google Scholar 

  • Lozzio BB, Lozzio CB, Bamberger EC, Lair SV (1975) Regulators of cell division: endogenous mitotic inhibitors of mammalian cells. Int Rev Cytol 42: 1–47

    Article  PubMed  CAS  Google Scholar 

  • Macieira-Coelho A (1988) Intracellular signal flow and genome activation. In: Bergener M, Ermini M, Stähelin HB (eds) Crossroads in aging. Academic Press, London, pp 3–23

    Google Scholar 

  • Macieira-Coelho A (1990) Cancer and aging at the cellular level. In: Macieira-Coelho A, Nordenskjöld B (eds) Cancer and aging. CRC Press, Boca Raton, pp 11–37

    Google Scholar 

  • Macieira-Coelho A, Avrameas S (1972) Modulation of cell behavior in vitro by the substratum in fibroblastic and leukemic mouse cell lines. Proc Natl Acad Sci USA 69: 2469–2473

    Article  PubMed  CAS  Google Scholar 

  • Macieira-Coelho A, Avrameas S (1973) Protein polymers as a substratum for the modulation of cell poliferation in vitro. In: Kruse PF, Patterson MK (eds) Tissue culture, methods and applications. Academic Press, New York, pp 379–383

    Google Scholar 

  • Macieira-Coelho A, Azzarone B (1990) Correlation between contractility and proliferation in human fibroblasts. J Cell Phys 142: 610–614

    Article  CAS  Google Scholar 

  • Macieira-Coelho A, Berumen L, Avrameas S (1974) Properties of protein polymers as substratum for cell growth in vitro. J Cell Phys 83: 379–388

    Article  CAS  Google Scholar 

  • Margolis LB, Rozovskaja IA, Cragoe E (1988) Intracellular pH and cell adhesion to solid substrate. FEBS Lett 234: 449–450

    Article  PubMed  CAS  Google Scholar 

  • Martin-Castellanos C, Moreno S (1997) Recent advances on cyclins, CDKs and CDK inhibitors. Trends Cell Biol 7: 95–98

    Google Scholar 

  • Montesano R, Orci L (1988) Transforming growth factor beta stimulates collagen-matrix contrac-tion by fibroblasts: implications for wound healing. Proc Natl Acad Sci USA 85: 4894–4897

    Article  PubMed  CAS  Google Scholar 

  • Moolenar WH, Tsien RY, Van der Saag PT, de Laat SW (1983) Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature 304: 645–648

    Article  Google Scholar 

  • Ohsawa T, Senshu T (1987) Exogenous GM1 ganglioside caused G1-arrest of human diploid fibroblasts. Flow cytometric studies. Exp Cell Res 173: 49–55

    Google Scholar 

  • Ortega JM, Meneghini R (1989) Competence growth factors can cause modification in higher- order chromatin structure in mouse embryo 3T3 fibroblasts. J Cell Biochem 40: 229–238

    Article  PubMed  CAS  Google Scholar 

  • Paulsson Y, Karlsson C, Heldin CH, Westermark B (1993) Density-dependent inhibitory effect of transforming growth factor-beta-1 on human fibroblasts involves the down-regulation of platelet-derived growth facotr alpha-receptors. J Cell Phys 157: 97–103

    Article  CAS  Google Scholar 

  • Pegg AE (1986) Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J 234: 249–262

    PubMed  CAS  Google Scholar 

  • Pockwinse SM, Krockmalnic G, Doxsey SJ, Nickerson J, Lian JB, Wijnen AJ van, Stein JL, Penman S (1997) Cell cycle-independent interaction of cdc2 with the centrosome which is associated with the nuclear matrix intermediate filament scaffold. Proc Natl Acad Sci USA 94: 3022–3027

    Article  PubMed  CAS  Google Scholar 

  • Reed SI (1997) Control of the G(1)/S transition. Cancer Sury 29: 25–46

    Google Scholar 

  • Reszka AA, Bulinski IC, Krebs EG, Fische EH (1997) Mitogen-activated protein kinase extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions. Mol Biol Cell 8: 1219–1232

    PubMed  CAS  Google Scholar 

  • Schwartz MA, Ingber DE, Lawrence M, Springer TA, Lechene C (1991) Multiple integrins share the ability to induce elevation of intracellular pH. Exp Cell Res 195: 533–535

    Article  PubMed  CAS  Google Scholar 

  • Spivack JG, Prusoff WH, Tritton TR (1984) Microinjection of pp60V-src into Xenopus oocytes increases phosphorylation of ribosomal protein S6 and accelerates the rate of progesterone-induced meiotic recombination. Mol Cell Biol 4: 1631–1634

    PubMed  CAS  Google Scholar 

  • Stockbridge LL, French AS (1988) Stretch-activated cation channels in human fibroblasts. Biophys J 54: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Thurston PW, Weeks JR (1984) The mathematics of three-dimensional manifolds. Sci Am July: 94–106

    Google Scholar 

  • Wahrmann JP, Delain D, Bournoutian C, Macieira-Coelho A (1981) Modulation of differentiation in vitro. I Influence of the attachment surface on myogenesis. In Vitro 17: 752–762

    Google Scholar 

  • Westergreen-Thorsson G, Persson S, Isakson A, Onnervik PO, Malmström A, Fransson LA (1993) L-iduronate-rich glycosaminoglycans inhibit growth of normal fibroblasts independently of serum or added growth factors. Exp Cell Res 206: 93–99

    Article  Google Scholar 

  • Weyer J, Schachtschabel DO, Sluke G, Weyer G (1980) Effect of short-or long-term treatment with exogenous glycosaminoglycans on growth and glycosaminoglycan synthesis of human fibroblasts (WI-38) in culture. Mech Ageing Dev 14: 89–99

    Article  Google Scholar 

  • Yen A, Sturgill A, Varvayanis S, Chern R (1996) FMS (CSF-1 receptor) prolongs cell cycle and promotes retinoic acid-induced hypophosphorylation of retinoblastoma protein, G1 arrest, and cell differentiation. Exp Cell Res 229: 111–125

    Google Scholar 

  • Zardi L, Siri A, Santi L (1976) A serum protein associated with chromatin of cultured fibroblasts. Science 191: 869–870

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM, 73 bis, rue du Maréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

Authors
  1. Alvaro Macieira-Coelho
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. INSERM, 73 bis, Rue du Maréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Macieira-Coelho, A. (1998). Introduction. In: Macieira-Coelho, A. (eds) Inhibitors of Cell Growth. Progress in Molecular and Subcellular Biology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72149-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72149-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72151-9

  • Online ISBN: 978-3-642-72149-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation