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Lessons from Knockout and Transgenic Mice

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Organtransplantation in Rats and Mice

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Abstract

Much has been learned in medicine through experiments of “nature”, the spontaneous mutations which affect important biological processes. One often learns more about the function of a product through its absence than through direct studies of its function. The effect of a mutation is characterized by its “phenotype” (a characteristic, e.g., a disease state) or in some cases by its surprising lack of a new phenotype, indicating that the gene is redundant. The lack of a new phenotype often challenges existing dogmas about allegedly essential mechanisms.

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Authors
  1. H. Wang
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  2. P. F. Halloran
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Editors and Affiliations

  1. Chirurgische Universitätsklinik und Poliklinik Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany

    Wolfgang Timmermann , Heinz-Jochen Gassel , Karin Ulrichs  & Arnulf Thiede , ,  & 

  2. Department of Surgery, University of Western Ontario, 339 Windermere Road, N6A 5A5, London, Ontario, Canada

    Robert Zhong

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Wang, H., Halloran, P.F. (1998). Lessons from Knockout and Transgenic Mice. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_32

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  • DOI: https://doi.org/10.1007/978-3-642-72140-3_32

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  • Online ISBN: 978-3-642-72140-3

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