Abstract
Despite refined immunosuppression and better surgical and perioperative management, improved long-term results of clinical organ transplantation have been hindered by chronic rejection [1], Transplant-associated arteriosclerosis is the most striking feature of chronic rejection. The incidence of coronary arteriosclerosis reaches 50% 5 years post-transplantation, leading to a 25% mortality rate in cardiac transplant patients [3]. Defining the pathogenesis of chronic rejection in patients is fraught with difficulties. For this reason a variety of animal models has been used [4, 5]. Aortic transplants in rats and mice develop vascular lesions resembling clinical arteriosclerosis, and this provides a useful tool to study the pathogenesis and treatment of transplant arteriosclerosis [6–8].
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© 1998 Springer-Verlag Berlin Heidelberg
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Jiang, J., Zhang, Z., Chow, L., Zhong, R. (1998). A Microsurgical Technique for Orthotopic Aorta Transplantation in Mice. In: Timmermann, W., Gassel, HJ., Ulrichs, K., Zhong, R., Thiede, A. (eds) Organtransplantation in Rats and Mice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72140-3_20
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DOI: https://doi.org/10.1007/978-3-642-72140-3_20
Publisher Name: Springer, Berlin, Heidelberg
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