Consensus Regarding Multiple-Day and Rescue Antiemetic Therapy
Different forms of moderately and highly emetogenic cancer chemotherapy that are administered over several days per cycle are discussed with reference to the most efficacious antiemetic therapy. Both preventive and rescue antiemetic therapy are considered.
KeywordsCorticosteroid Dexamethasone Cataract Methylprednisolone Bleomycin
Unable to display preview. Download preview PDF.
- 2.Bremer K on behalf of the granisetron study group (1992) A single-blind study of the efficacy and safety of intravenous granisetron compared with alizapride plus dexamethasone in the prophylaxis and control of emesis in patients receiving 5-day cytostatic therapy. Eur J Cancer [A] 28: 1018–1022CrossRefGoogle Scholar
- 3.Buser KS, Joss RA, Piquet D et al (1993) Oral ondansetron in the prophylaxis of nausea and vomiting induced by cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in women with breast cancer. Results of a prospective, randomized, double-blind placebocontrolled study. Ann Oncol 4: 474–479Google Scholar
- 4.deBoer M, de Wit R, Stoter G, Verweij J (1995) Possible lack of full cross-resistance of 5HT3 antagonists: a pilot study. Cancer Res Clin Oncol 121: 126–127Google Scholar
- 5.Depierre A, Lebeau B, Chevallier B et al (1996) Efficay of ondansetron, methylprednisolone plus metopimazine in patients previously incontrolled with dual therapy in cisplatin containing chemotherapy (abstract). Ann Oncol 7: 134Google Scholar
- 14.Mantovani G, Macciò A, Alessandro B, Curelli L, Ghiani M, Proto E (1996) Comparison of granisetron versus ondansetron versus tropisetron in the prophylaxis of acute nausea and vomiting induced by cisplatin for the treatment of head and neck cancer: a randomized controlled trial. Cancer 77: 941–948PubMedCrossRefGoogle Scholar