Molecular Mechanisms of Persistent Infection by Reovirus
Many cytolytic animal viruses are capable of establishing persistent infections of cultured cells. For such persistent infections to be maintained interactions between virus and cell must be modulated such that a less cytopathic virus-host relationship is established (reviewed in Ahmed et al. 1996). Variant viruses may be selected that are attenuated in cytolytic potential, or variant cells may be selected that are less permissive for viral replication. In some cases, however, viruses and cells coevolve during persistent infection, such that selection of virus-resistant cells leads to counterselection of highly infective mutant viruses that can grow in resistant cells.
KeywordsZinc Attenuation Tyrosine Amide Influenza
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- Ahmed R, Morrison LA, Knipe DM (1996) Persistence of viruses. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, pp 219–249Google Scholar
- Brown EG, Nibert ML, Fields BN (1983) The L2 gene of reovirus serotype 3 controls the capacity to interfere, accumulate deletions and establish persistent infection. In: Compans RW, Bishop DHL (eds) Double-stranded RNA viruses. Elsevier Biomedical, New York, pp 275–287Google Scholar
- Dryden KA, Wang G, Yeager M, Nibert ML, Coombs KM, Furlong DB, Fields BN, Baker TS (1993) Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy and image reconstruction. J Cell Biol 122: 1023–1041PubMedCrossRefGoogle Scholar
- Fenner F, Kerr PJ (1994) Evolution of the poxviruses, including the coevolution of virus and host in myxomatosis In: Morse SS (ed) The evoluticmary biology of viruses. Raven, New York, pp 273–292Google Scholar
- Mrukowicz J, Wetzel JD, Goral MI, Fogo AB, Wright PF, Dermody TS (1997) Viruses and cells with mutations affecting viral entry are selected during persistent rotavirus infections of MA104 cells. J Virol 72 (in press)Google Scholar
- Nibert ML, Schiff LA, Fields BN (1996) Reoviruses and their replication. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology, 3rd edn. Lippincott-Raven, Philadelphia, pp 1557–1596Google Scholar
- Sharpe AH, Fields BN (1983) Pathogenesis of reovirus infection. In: Joklik WK (eds) The reoviridae. Plenum, New York, pp 229–285Google Scholar
- Whitton JL, Oldstone MBA (1996) Immune responses to viruses. In: Fields BN, Knipe DM, Howley PM (eds) Fields virology. Lippincott-Raven, Philadelphia, pp 345–374Google Scholar