Molecular Mechanisms of Persistent Infection by Reovirus
Many cytolytic animal viruses are capable of establishing persistent infections of cultured cells. For such persistent infections to be maintained interactions between virus and cell must be modulated such that a less cytopathic virus-host relationship is established (reviewed in Ahmed et al. 1996). Variant viruses may be selected that are attenuated in cytolytic potential, or variant cells may be selected that are less permissive for viral replication. In some cases, however, viruses and cells coevolve during persistent infection, such that selection of virus-resistant cells leads to counterselection of highly infective mutant viruses that can grow in resistant cells.
KeywordsPersistent Infection Ammonium Chloride Viral Entry Semliki Forest Virus Reovirus Infection
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