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Reoviruses I pp 137–153Cite as

Reovirus Cell Attachment Protein σ1: Structure-Function Relationships and Biogenesis

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/1))

Abstract

The reovirus σ1 protein is encoded by the S1 gene segment and is probably the most extensively studied of all reovirus proteins. This is mainly because σl is the reovirus cell attachment protein and, as such, represents the first viral protein the cell encounters during reovirus invasion. As fibrous structures extending from the 12 vertices of the viral icosahedron, σl allows ready access of the virus to host cell receptors as well as multivalent binding, which is important for the subsequent virus internalization step. While the cell-binding function of σl can be readily demonstrated in vitro, the in vivo functions of σl have been deduced mainly from studies of animals infected with genetic reassortants derived from the three reovirus serotypes. It is interesting to note that most of the in vivo functions ascribed to σl can be explained by its cell-binding activity.

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Authors and Affiliations

  1. Department of Microbiology and Infectious Diseases, University of Calgary, T2N 4N1, Calgary, Alberta, Canada

    P. W. K. Lee & R. Gilmore

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  1. P. W. K. Lee
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  2. R. Gilmore
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Editors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box B-182, 80262, Denver, CO, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone M.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Lee, P.W.K., Gilmore, R. (1998). Reovirus Cell Attachment Protein σ1: Structure-Function Relationships and Biogenesis. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses I. Current Topics in Microbiology and Immunology, vol 233/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72092-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-72092-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-72092-5

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