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The Role of the Host Defense Response in the Progression and Outcome of ARDS

  • G. U. Meduri
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1998)

Abstract

Acute respiratory distress syndrome (ARDS) describes the clinical syndrome associated with the morphologic lesion termed diffuse alveolar damage (DAD). At presentation, (early) ARDS manifests with acute and diffuse injury to the endothelial and epithelial lining of the terminal respiratory units and causes increased vascular permeability with protein-rich exudative edema. In non-survivors of ARDS, DAD rapidly advances through three histological phases (exudative, fibroproliferative, and fibrotic) with different clinico-physiologic features. The objective of this review is to describe systematically the pathophysiology of unresolving ARDS relating to mechanisms of its development, structural alterations induced in the lung, and functional consequences of these morphologic changes.

Keywords

Idiopathic Pulmonary Fibrosis Systemic Inflammatory Response Syndrome Acute Respiratory Distress Syndrome Disseminate Intravascular Coagulation Adult Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

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  • G. U. Meduri

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