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α4 Integrins and Tumor Metastasis

  • Chapter
Leukocyte Integrins in the Immune System and Malignant Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 231))

Abstract

Neoplastic cells selected to form metastatic tumors pass through a cascade of events that are initiated by detachment from the primary tumor mass and invasion of the adjacent tissue (Liotta et al. 1991; Nicolson 1982; Stetler-Stevenson et al. 1993). The migration through the interstitial stroma, mainly comprised of extracellular matrix proteins such as vitronectin, collagens or fibronectin, is followed by entry into the vasculature, either by transport through the lymphatic vessels and lymphaticovascular connections or by active movement across the endothelial barrier. After dissemination through the circulation, which is a crucial step for the survival of metastatic cells, the tumor cells arrest in the microvasculature of distant organs as single cells, tumor cell emboli, or tumor cell-platelet emboli via interaction with vascular endothelium or subendothelial basement membrane. After extravasation and invasion of the target organ disseminated cells expand and generate secondary tumors.

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  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University, Trogerstraße 9, 81675, Munich, Germany

    B. Holzmann, U. Gosslar & M. Bittner

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  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675, Munich, Germany

    Bernhard Holzmann M.D.  & Hermann Wagner M.D., Ph.D.  & 

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Holzmann, B., Gosslar, U., Bittner, M. (1998). α4 Integrins and Tumor Metastasis. In: Holzmann, B., Wagner, H. (eds) Leukocyte Integrins in the Immune System and Malignant Disease. Current Topics in Microbiology and Immunology, vol 231. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71987-5_8

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