α4 Integrins and Tumor Metastasis

  • B. Holzmann
  • U. Gosslar
  • M. Bittner
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 231)


Neoplastic cells selected to form metastatic tumors pass through a cascade of events that are initiated by detachment from the primary tumor mass and invasion of the adjacent tissue (Liotta et al. 1991; Nicolson 1982; Stetler-Stevenson et al. 1993). The migration through the interstitial stroma, mainly comprised of extracellular matrix proteins such as vitronectin, collagens or fibronectin, is followed by entry into the vasculature, either by transport through the lymphatic vessels and lymphaticovascular connections or by active movement across the endothelial barrier. After dissemination through the circulation, which is a crucial step for the survival of metastatic cells, the tumor cells arrest in the microvasculature of distant organs as single cells, tumor cell emboli, or tumor cell-platelet emboli via interaction with vascular endothelium or subendothelial basement membrane. After extravasation and invasion of the target organ disseminated cells expand and generate secondary tumors.


Melanoma Cell Metastasis Formation Metastatic Capacity Homotypic Adhesion Tumor Cell Embolus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. Holzmann
    • 1
  • U. Gosslar
    • 1
  • M. Bittner
    • 1
  1. 1.Institute of Medical Microbiology, Immunology, and HygieneTechnical UniversityMunichGermany

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