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Functions of α4- and β7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development

  • Chapter
Leukocyte Integrins in the Immune System and Malignant Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 231))

Abstract

The family of integrins comprise more than 20 αβ(3 heterodimeric membrane bound glycoproteins that mediate cell-cell and cell-extracellular matrix contacts. To date, 16 α and eight β subunits assemble noncovalently in a variety of combinations. In most instances, α chains associate with only one β chain while β chains are promiscuous. However, the α4 and αv subunits both associate with more than one β chain. Subfamilies of integrins are named according to the β chain used. The largest subfamily comprises the βi-integrins consisting of at least nine members. The integrins function as adhesion molecules as well as signal transducers by binding to a number of ligands (Clark and Brugge 1995; Zimmermann et al. 1996). Such ligands are either extracellular matrix proteins like fibronectin, laminin and vitronectin or members of the Ig superfamily like the intercellular adhesion molecules (ICAMs), the vascular cell adhesion molecule (VCAM-1) and the mucosal addressin cell adhesion molecule (MAdCAM-1).

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Authors and Affiliations

  1. Institute for Genetics, University of Cologne, Weyertal 121, 50931, Köln, Germany

    N. Wagner & W. Müller

  2. Dept. of Pediatrics, University of Bonn, Bonn, Germany

    N. Wagner

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  1. N. Wagner
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  2. W. Müller
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Editors and Affiliations

  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675, Munich, Germany

    Bernhard Holzmann M.D.  & Hermann Wagner M.D., Ph.D.  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Wagner, N., Müller, W. (1998). Functions of α4- and β7-Integrins in Hematopoiesis, Lymphocyte Trafficking and Organ Development. In: Holzmann, B., Wagner, H. (eds) Leukocyte Integrins in the Immune System and Malignant Disease. Current Topics in Microbiology and Immunology, vol 231. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71987-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-71987-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71989-9

  • Online ISBN: 978-3-642-71987-5

  • eBook Packages: Springer Book Archive

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