Familial and Hereditary Non-polyposis Colorectal Cancer: Issues Relevant for Surgical Practice

  • F. H. Menko
  • J. T. Wijnen
  • H. F. A. Vasen
  • R. H. Sijmons
  • P. Meera Khan
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 146)

Abstract

About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%–5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.

Keywords

Manifold Codon Adenocarcinoma Adenoma Electrophoresis 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1998

Authors and Affiliations

  • F. H. Menko
    • 1
  • J. T. Wijnen
    • 2
  • H. F. A. Vasen
    • 3
  • R. H. Sijmons
    • 4
  • P. Meera Khan
    • 2
  1. 1.Department of Clinical GeneticsUniversity Hospital Vrije UniversiteitAmsterdamThe Netherlands
  2. 2.Department of Human Genetics, Medical Genetics Center, Sylvius LaboratoriesLeiden UniversityLeidenThe Netherlands
  3. 3.Foundation for the Detection of Hereditary TumoursLeidenThe Netherlands
  4. 4.Department of Medical Genetics, Faculty of MedicineUniversity of GroningenGroningenThe Netherlands

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