Familial and Hereditary Non-polyposis Colorectal Cancer: Issues Relevant for Surgical Practice
About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%–5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.
KeywordsColorectal Cancer Endometrial Cancer Lynch Syndrome Amsterdam Criterion Large Bowel Cancer
Unable to display preview. Download preview PDF.
- Stjohn DJB, McDermott FT, Hopper JL et al. (1993) Cancer risk in relatives of patients with common colorectal cancer. Ann Intern Med 118:785–790Google Scholar